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PubMed: 23948915

Title
Phosphorylation of tau by death-associated protein kinase 1 antagonizes the kinase-induced cell apoptosis.
Journal
Journal of Alzheimer's disease : JAD
Volume
37
Issue
None
Pages
795-808
Date
2013-01-01
Authors
Chai GS | Chen NN | Cheng XS | Duan DX | Hu Y | Liu GP | Luo Y | Ni ZF | Wang JZ

Evidence c8762f7a9f
JSON

These data suggest that tau hyperphosphorylation at Thr231, Ser262, and Ser396 by DAPK1 renders the cells more resistant to the kinase-induced apoptotic cell death, providing new insights into the tau-involved apoptotic abortion in the course of chronic neurodegeneration.

bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) View Subject | View Object

Appears in Networks:

bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) View Subject | View Object

Appears in Networks:

bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph, Ser, 396)) negativeCorrelation bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) View Subject | View Object

Appears in Networks:

p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) View Subject | View Object

Appears in Networks:

p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

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