p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 396))

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PubMed:23948915

These data suggest that tau hyperphosphorylation at Thr231, Ser262, and Ser396 by DAPK1 renders the cells more resistant to the kinase-induced apoptotic cell death, providing new insights into the tau-involved apoptotic abortion in the course of chronic neurodegeneration.

Related Edges 8

• bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))
• bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
• bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231))
• p(HGNC:MAPT, pmod(Ph, Ser, 396)) negativeCorrelation bp(GO:"apoptotic process")
• p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 262))
• p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
• p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation bp(GO:"apoptotic process")
• p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation bp(GO:"apoptotic process")

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