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PubMed: 26655600

Title
Glycation alter the process of Tau phosphorylation to change Tau isoforms aggregation property.
Journal
Biochimica et biophysica acta
Volume
1862
Issue
None
Pages
192-201
Date
2016-02-01
Authors
Deng Y | Iqbal J | Li L | Liu K | Liu Y | Qin P | Qing H

Evidence c494fa850e
JSON

However, granule cells of the dentate gyrus mainly express 3R isoforms, which resist Tau aggregation in AD, but accumulate 3R aggregates in Pick's disease [14]. 3R Tau is a major Tau isoform in laser microdissected Pick bodies [15].

bp(GO:"neurofibrillary tangle assembly") negativeCorrelation p(HBP:"3R tau") View Subject | View Object

Appears in Networks:
Annotations
Uberon
dentate gyrus granule cell layer
Disease Ontology (DO)
Alzheimer's disease

complex(GO:"Pick body") positiveCorrelation p(HBP:"3R tau") View Subject | View Object

Appears in Networks:
Annotations
Uberon
dentate gyrus granule cell layer
Disease Ontology (DO)
Pick's disease

p(HBP:"3R tau") negativeCorrelation bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:
Annotations
Uberon
dentate gyrus granule cell layer
Disease Ontology (DO)
Alzheimer's disease

p(HBP:"3R tau") positiveCorrelation complex(GO:"Pick body") View Subject | View Object

Appears in Networks:
Annotations
Uberon
dentate gyrus granule cell layer
Disease Ontology (DO)
Pick's disease

Evidence 5bc641bf18
JSON

The results show that 4R2N and 3R2N Tau increase their aggregation extent with glycation while 3R1N decreases aggregation properties with glycation

p(HBP:"Tau isoform B (381 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform C (410 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:

Evidence be144361a5
JSON

Despite 4R1N having no significant change, the same modified 4R2N Tau promotes its aggregation significantly (Fig. 6A, C, E).

p(HBP:"Tau isoform B (381 aa)", pmod(Ph)) increases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:

Evidence f39fb0d431
JSON

Glycation and phosphorylation of both 4R1Nand 4R0NTau reduce its aggregation.

p(HBP:"Tau isoform D (383 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform D (383 aa)", pmod(Ph)) decreases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform E (412 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform E (412 aa)", pmod(Ph)) decreases bp(GO:"neurofibrillary tangle assembly") View Subject | View Object

Appears in Networks:

Evidence 14884534e7
JSON

On the other hand, the MS analysis shows that in the combined reaction of 4R2N Tau the level of phosphorylation is increased and the level of glycation is decreased.

p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(Ph)) View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", pmod(Ph)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) View Subject | View Object

Appears in Networks:

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