complex(GO:"Pick body")
Double immunostaining for PICALM and anti-phosphotau antibodies (AT8 and PHF1) showed a co-localisation of PICALM and phosphotau in Pick bodies of Pick disease PubMed:27260836
However, granule cells of the dentate gyrus mainly express 3R isoforms, which resist Tau aggregation in AD, but accumulate 3R aggregates in Pick's disease [14]. 3R Tau is a major Tau isoform in laser microdissected Pick bodies [15]. PubMed:26655600
Double immunostaining for PICALM and anti-phosphotau antibodies (AT8 and PHF1) showed a co-localisation of PICALM and phosphotau in Pick bodies of Pick disease PubMed:27260836
However, granule cells of the dentate gyrus mainly express 3R isoforms, which resist Tau aggregation in AD, but accumulate 3R aggregates in Pick's disease [14]. 3R Tau is a major Tau isoform in laser microdissected Pick bodies [15]. PubMed:26655600
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.