Title

Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure.

Journal

The Journal of biological chemistry

Volume

276

Issue

None

Pages

48165-74

Date

2001-12-21

Authors

Barghorn S | Biernat J | Li L | Mandelkow E | Mandelkow EM | Marx A | von Bergen M

We also show that two of the tau mutations found in hereditary frontotemporal dementias, DeltaK280 and P301L, have a much stronger tendency for PHF aggregation which correlates with their high propensity for beta-structure around the hexapeptide motifs.

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