p(HBP:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))

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PubMed:11606569

We also show that two of the tau mutations found in hereditary frontotemporal dementias, DeltaK280 and P301L, have a much stronger tendency for PHF aggregation which correlates with their high propensity for beta-structure around the hexapeptide motifs.

Related Edges 9

• p(HBP:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del"))
• p(HBP:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu"))
• p(HBP:"VQIINK motif") increases p(HBP:"Tau aggregates")
• p(HBP:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del"))
• p(HBP:"VQIVYK motif") increases p(HBP:"Tau aggregates")
• p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HBP:"VQIVYK motif")
• p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HBP:"VQIINK motif")
• p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HBP:"VQIVYK motif")
• p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HBP:"VQIINK motif")

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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