Title

Protein Phosphatase 1 dephosphorylates TDP-43 and suppresses its function in tau exon 10 inclusion.

Journal

FEBS letters

Volume

592

Issue

None

Pages

402-410

Date

2018-02-01

Authors

Chen F | Gong CX | Gu J | Hu W | Iqbal K | Liu F | Miao S | Wang W | Wu F

We recently found that overexpression of TDP-43 enhances tau exon 10 inclusion and tau mRNA instability. Overexpression of PP1α and PP1γ, but not PP1β, suppressed TDP-43 phosphorylation at Ser403/404 and Ser409/410 and TDP-43-induced tau exon 10 inclusion.

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