act(p(HGNC:TARDBP)) increases p(HBP:"4R tau")

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PubMed:29334120

We recently found that overexpression of TDP-43 enhances tau exon 10 inclusion and tau mRNA instability. Overexpression of PP1α and PP1γ, but not PP1β, suppressed TDP-43 phosphorylation at Ser403/404 and Ser409/410 and TDP-43-induced tau exon 10 inclusion.

Related Edges 11

• p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 397))
• p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 403))
• p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 404))
• p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 409))
• p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 410))
• p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 403))
• p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 404))
• p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 409))
• p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 410))
• p(HGNC:TARDBP, pmod(Ph, Ser, 409)) increases act(p(HGNC:TARDBP))
• p(HGNC:TARDBP, pmod(Ph, Ser, 410)) increases act(p(HGNC:TARDBP))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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