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PubMed: 26837465

Title
Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease.
Journal
Scientific reports
Volume
6
Issue
None
Pages
20352
Date
2016-02-03
Authors
Jiang S | Perry G | Shen L | Siedlak SL | Tang B | Wang C | Wang X | Zhang F | Zhu X

Evidence 6f1fc78699
JSON

In the hippocampal and cortical tissues of all AD cases examined, neuronal staining for ERα was a prominent finding, both with a weak cytoplasmic stain, but often specifically with a fibrillar appearance suggesting ERα was in neurofibrillary tangles (Fig. 1A), also shown at a higher magnification (Fig. 1B).

complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Hippocampus

p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Hippocampus

Evidence d2ea2e29f3
JSON

To confirm the localization of ERα in NFTs, double fluorescence staining with antibodies to ERα and hyperphosphorylated tau (PHF-1) revealed that ERα -positive NFTs were also positive for PHF-1 (Fig. 2A–F).

p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association p(HGNC:ESR1) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Hippocampus

complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Hippocampus

p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Hippocampus

p(HGNC:ESR1) association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Hippocampus

Evidence 3fbaf7af37
JSON

Tau overexpression inhibits transcriptional activity of ERα.

p(HGNC:MAPT) decreases act(p(HGNC:ESR1), ma(tscript)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Cerebral Cortex
MeSH
Hippocampus

Evidence c5609d0931
JSON

Moreover, more ERα was found in the tau-5 immunoprecipitates from AD brain than control brain (p < 0.05) (Fig. 5B,C), demonstrating increased interaction between tau and ERα in the AD brain which is likely the mechanism that underlies increased sequestration of ERα by the PHFs in NFTs.

path(MESH:"Alzheimer Disease") increases complex(p(HGNC:ESR1), p(HGNC:MAPT)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Cerebral Cortex
MeSH
Hippocampus

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.