Title

Nuclear tau, a key player in neuronal DNA protection.

Journal

The Journal of biological chemistry

Volume

286

Issue

None

Pages

4566-75

Date

2011-02-11

Authors

Buée L | Sultan A | Galas MC | Bonnefoy E | Bégard S | Colin M | Humez S | Loyens A | Mansuroglu Z | Marzin D | Nesslany F | Sergeant N | Talahari S | Violet M

In this work, we demonstrate that acute oxidative stress and mild heat stress (HS) induce the accumulation of dephosphorylated Tau in neuronal nuclei. Using chromatin immunoprecipitation assays, we demonstrate that the capacity of endogenous Tau to interact with neuronal DNA increased following HS. Comet assays performed on both wildtype and Tau-deficient neuronal cultures showed that Tau fully protected neuronal genomic DNA against HS-induced damage. Interestingly, HS-induced DNA damage observed in Tau-deficient cells was completely rescued after the overexpression of human Tau targeted to the nucleus.

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