bp(MESH:"Oxidative Stress") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus))

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PubMed:21131359

In this work, we demonstrate that acute oxidative stress and mild heat stress (HS) induce the accumulation of dephosphorylated Tau in neuronal nuclei. Using chromatin immunoprecipitation assays, we demonstrate that the capacity of endogenous Tau to interact with neuronal DNA increased following HS. Comet assays performed on both wildtype and Tau-deficient neuronal cultures showed that Tau fully protected neuronal genomic DNA against HS-induced damage. Interestingly, HS-induced DNA damage observed in Tau-deficient cells was completely rescued after the overexpression of human Tau targeted to the nucleus.

Related Edges 7

• a(CHEBI:"double-stranded DNA") association p(HGNC:MAPT)
• bp(MESH:"Hot Temperature") increases complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT))
• bp(MESH:"Hot Temperature") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus))
• bp(MESH:"Hot Temperature") negativeCorrelation p(HGNC:MAPT)
• bp(MESH:"Hot Temperature") decreases a(CHEBI:"double-stranded DNA")
• p(HGNC:MAPT) association a(CHEBI:"double-stranded DNA")
• p(HGNC:MAPT) negativeCorrelation bp(MESH:"Hot Temperature")

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