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PubMed: 20133804

Title
A role for FKBP52 in Tau protein function.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Volume
107
Issue
None
Pages
2658-63
Date
2010-02-09
Authors
Goedert M | Giustiniani J | Dounane O | Schumacher M | Sardin E | Baulieu EE | Chambraud B

Evidence a1ee27d2da
JSON

We concluded that FKBP52 inhibits the promotion of microtubule assembly by Tau.

bp(GO:"microtubule polymerization") positiveCorrelation complex(GO:microtubule) View Subject | View Object

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complex(GO:microtubule) positiveCorrelation bp(GO:"microtubule polymerization") View Subject | View Object

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p(RGD:Fkbp4) decreases act(p(RGD:Mapt)) View Subject | View Object

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act(p(RGD:Mapt)) increases bp(GO:"microtubule polymerization") View Subject | View Object

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Evidence 14774cee17
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Because one role of Tau is to stimulate neurite outgrowth (12), we investigated the consequence of FKBP52 overexpression on neurite length in both PC12 and H7C2 cells. The inhibition of neurite outgrowth resulting from FKBP52 overexpression is in agreement with our previous report showing that the loss of FKBP52 in PC12 cells results in the formation of neurite extensions (9). The FKBP52 effect on neurite length could be explained by the binding of Tau to FKBP52, removing Tau from microtubules.

bp(GO:"neuron projection development") negativeCorrelation p(RGD:Fkbp4) View Subject | View Object

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Annotations
Experimental Factor Ontology (EFO)
PC12

p(RGD:Fkbp4) negativeCorrelation bp(GO:"neuron projection development") View Subject | View Object

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Annotations
Experimental Factor Ontology (EFO)
PC12

act(p(RGD:Mapt)) increases bp(GO:"neuron projection development") View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12

Evidence f466bad16d
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In addition to its peptidyl–prolyl isomerase activity, FKBP52 serves as a molecular chaperone. This activity depends on its tetratricopeptide repeat domain (27) to which the molecular chaperone HSP90 and other proteins bind.

p(SFAM:"HSP90 Family") association p(HGNC:FKBP4, frag("270_386")) View Subject | View Object

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p(HGNC:FKBP4, frag("270_386")) association p(SFAM:"HSP90 Family") View Subject | View Object

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Evidence ffddd50a72
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Thus, Tau and FKBP52 form a complex in rat brain. These findings indicate a direct interaction between FKBP52 and Tau. As shown in Fig. 3B, the amount of FKBP52 recruited by Tau depends on its phosphorylation state.In any case, these results underline the importance of Tau phosphorylation for its binding to FKBP52.

p(RGD:Fkbp4) positiveCorrelation p(RGD:Mapt, pmod(Ph)) View Subject | View Object

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p(RGD:Mapt, pmod(Ph)) positiveCorrelation p(RGD:Fkbp4) View Subject | View Object

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