1. Catalog
  2. Nodes
  3. p(RGD:Fkbp4)

p(RGD:Fkbp4)

Equivalencies: 0 | Classes: 1 | Children: 0 | Explore

Entity

Name
Fkbp4
Namespace
rgd
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/rgd-names.belns

Appears in Networks 1

TAU and Interaction Partners v1.2.5

TAU Interactions Section of NESTOR

In-Edges 3

bp(GO:"neuron projection development") negativeCorrelation p(RGD:Fkbp4) View Subject | View Object

Because one role of Tau is to stimulate neurite outgrowth (12), we investigated the consequence of FKBP52 overexpression on neurite length in both PC12 and H7C2 cells. The inhibition of neurite outgrowth resulting from FKBP52 overexpression is in agreement with our previous report showing that the loss of FKBP52 in PC12 cells results in the formation of neurite extensions (9). The FKBP52 effect on neurite length could be explained by the binding of Tau to FKBP52, removing Tau from microtubules. PubMed:20133804

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12

complex(p(RGD:Fkbp4), p(RGD:Mapt, pmod(Ph))) hasComponent p(RGD:Fkbp4) View Subject | View Object

Appears in Networks:

p(RGD:Mapt, pmod(Ph)) positiveCorrelation p(RGD:Fkbp4) View Subject | View Object

Thus, Tau and FKBP52 form a complex in rat brain. These findings indicate a direct interaction between FKBP52 and Tau. As shown in Fig. 3B, the amount of FKBP52 recruited by Tau depends on its phosphorylation state.In any case, these results underline the importance of Tau phosphorylation for its binding to FKBP52. PubMed:20133804

Appears in Networks:

Out-Edges 4

p(RGD:Fkbp4) positiveCorrelation p(RGD:Mapt, pmod(Ph)) View Subject | View Object

Thus, Tau and FKBP52 form a complex in rat brain. These findings indicate a direct interaction between FKBP52 and Tau. As shown in Fig. 3B, the amount of FKBP52 recruited by Tau depends on its phosphorylation state.In any case, these results underline the importance of Tau phosphorylation for its binding to FKBP52. PubMed:20133804

Appears in Networks:

p(RGD:Fkbp4) isA complex(p(RGD:Fkbp4), p(RGD:Mapt, pmod(Ph))) View Subject | View Object

Appears in Networks:

p(RGD:Fkbp4) decreases act(p(RGD:Mapt)) View Subject | View Object

We concluded that FKBP52 inhibits the promotion of microtubule assembly by Tau. PubMed:20133804

Appears in Networks:

p(RGD:Fkbp4) negativeCorrelation bp(GO:"neuron projection development") View Subject | View Object

Because one role of Tau is to stimulate neurite outgrowth (12), we investigated the consequence of FKBP52 overexpression on neurite length in both PC12 and H7C2 cells. The inhibition of neurite outgrowth resulting from FKBP52 overexpression is in agreement with our previous report showing that the loss of FKBP52 in PC12 cells results in the formation of neurite extensions (9). The FKBP52 effect on neurite length could be explained by the binding of Tau to FKBP52, removing Tau from microtubules. PubMed:20133804

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.