p(HGNC:CHRM1) association bp(GO:"neuronal signal transduction")

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PubMed:24590577

Among the mAChR family members, the M1 subtype makes up 50–60% of the total and is predominantly expressed in all major areas of the forebrain, including the hippocampus, cerebral cortex, corpus striatum, and thalamus[36-38]. M1 mAChR-knockout mice show a series of cognitive defi cits and impairments in long-term potentiation, indicating that the M1 subtype is physiologically linked to multiple functions such as synaptic plasticity, neuronal excitability, neuronal differentiation during early development, and learning and memory

Related Edges 19

• a(MESH:"Cerebral Cortex") association p(HGNC:CHRM1)
• a(MESH:"Corpus Striatum") association p(HGNC:CHRM1)
• a(MESH:Hippocampus) association p(HGNC:CHRM1)
• a(MESH:Thalamus) association p(HGNC:CHRM1)
• bp(GO:"neuron differentiation") association p(HGNC:CHRM1)
• bp(GO:"neuronal signal transduction") association p(HGNC:CHRM1)
• bp(GO:"regulation of synaptic plasticity") association p(HGNC:CHRM1)
• bp(GO:learning) association p(HGNC:CHRM1)
• bp(GO:memory) association p(HGNC:CHRM1)
• p(HGNC:CHRM1) association a(MESH:Hippocampus)
• p(HGNC:CHRM1) association a(MESH:"Cerebral Cortex")
• p(HGNC:CHRM1) association a(MESH:"Corpus Striatum")
• p(HGNC:CHRM1) association a(MESH:Thalamus)
• p(HGNC:CHRM1) association bp(GO:"regulation of synaptic plasticity")
• p(HGNC:CHRM1) association bp(GO:learning)
• p(HGNC:CHRM1) association bp(GO:memory)
• p(HGNC:CHRM1) association bp(GO:"neuron differentiation")
• p(MGI:Chrm1) increases bp(GO:cognition)
• p(MGI:Chrm1) increases bp(GO:"long-term synaptic potentiation")

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