composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) decreases bp(GO:"retrograde axonal protein transport")

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PubMed:27373205

In contrast to hT40 monomer, perfusion of S422E monomer selectively inhibited anterograde transport (Fig. 5C; Fig. 6A; p = 0.028), but not retrograde FAT. Surprisingly, aggregated S422E significantly inhibited both anterograde and retrograde FAT rates (Fig. 5D; Fig. 6A, B) compared to S422E monomer (anterograde, p = 0.012; retrograde, p = 0.002) and hT40 aggregates (retrograde only, p = 0.019).

Related Edges 3

• composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) decreases bp(GO:"anterograde axonal protein transport")
• p(HGNC:MAPT, var("p.S422E")) decreases bp(GO:"anterograde axonal protein transport")
• p(HGNC:MAPT, var("p.S422E")) causesNoChange bp(GO:"retrograde axonal protein transport")

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