bp(GO:aging) positiveCorrelation path(MESH:"Alzheimer Disease")

View Subject View Object

PubMed:24561250

Aging, another risk factor of AD, has been found to activate the NLRP1 inflammasome and upregulate IL-18 and IL-1β levels in the hippocampus of aged mice (Mawhinney et al., 2011)

Related Edges 4

• bp(GO:aging) increases act(complex(GO:"NLRP1 inflammasome complex"))
• bp(GO:aging) increases p(HGNC:IL1B)
• bp(GO:aging) increases p(HGNC:IL18)
• path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:aging)

Confidence

Medium

MeSH

Hippocampus

NeuroMMSigDB

Interleukin signaling subgraph

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---