a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crh))

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PubMed:8940412

Antalarmin potently displaced 1251-oCRH binding, exhibiting respectively Ki values of 1. 9 f 0.9,. 1.3 f .4, and 1.4 f .6 nM (mean f SEM) in pituitary, cerebellum, and frontal cortex homogenates.Antalarmin, by effectively displacing IoCRH binding in tissues predominately expressing CRHRl but not in tissues expressing CRHR2, appears to be a specific CRHRl receptor antagonist.

Related Edges 2

• a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crhr1))
• act(p(RGD:Crh)) directlyIncreases act(p(RGD:Crhr1))

Uberon

pituitary gland

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