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p(RGD:Crh)

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Entity

Name
Crh
Namespace
rgd
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/rgd-names.belns

Appears in Networks 1

In Vivo and In Vitro Characterization of Antalarmin, a Nonpeptide Corticotropin-Releasing Hormone (CRH) Receptor Antagonist: Suppression of Pituitary ACTH Release and Peripheral Inflammation v1.0.0

In-Edges 2

a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crh)) View Subject | View Object

Antalarmin potently displaced 1251-oCRH binding, exhibiting respectively Ki values of 1. 9 f 0.9,. 1.3 f .4, and 1.4 f .6 nM (mean f SEM) in pituitary, cerebellum, and frontal cortex homogenates.Antalarmin, by effectively displacing IoCRH binding in tissues predominately expressing CRHRl but not in tissues expressing CRHR2, appears to be a specific CRHRl receptor antagonist. PubMed:8940412

Appears in Networks:
Annotations
Uberon
pituitary gland

bp(GO:"inflammatory response") positiveCorrelation act(p(RGD:Crh)) View Subject | View Object

Corticotropin-releasing hormone (CRH) secreted from the hypothalamus is the major regulator of pituitary ACTH release and consequent glucocorticoid secretion. CRH secreted in the periphery also acts as a proinflammatory modulator. PubMed:8940412

Appears in Networks:

Out-Edges 3

act(p(RGD:Crh)) positiveCorrelation bp(GO:"inflammatory response") View Subject | View Object

Corticotropin-releasing hormone (CRH) secreted from the hypothalamus is the major regulator of pituitary ACTH release and consequent glucocorticoid secretion. CRH secreted in the periphery also acts as a proinflammatory modulator. PubMed:8940412

Appears in Networks:

act(p(RGD:Crh)) regulates sec(p(RGD:Pomc)) View Subject | View Object

Corticotropin-releasing hormone (CRH) secreted from the hypothalamus is the major regulator of pituitary ACTH release and consequent glucocorticoid secretion. CRH secreted in the periphery also acts as a proinflammatory modulator. PubMed:8940412

Appears in Networks:

act(p(RGD:Crh)) directlyIncreases act(p(RGD:Crhr1)) View Subject | View Object

Antalarmin potently displaced 1251-oCRH binding, exhibiting respectively Ki values of 1. 9 f 0.9,. 1.3 f .4, and 1.4 f .6 nM (mean f SEM) in pituitary, cerebellum, and frontal cortex homogenates.Antalarmin, by effectively displacing IoCRH binding in tissues predominately expressing CRHRl but not in tissues expressing CRHR2, appears to be a specific CRHRl receptor antagonist. PubMed:8940412

Appears in Networks:
Annotations
Uberon
pituitary gland

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.