p(HBP:"CDK5R1 p25") negativeCorrelation p(HGNC:CDK5R1)

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PubMed:26118667

To perform its function, Cdk5 must bind to the neuron-specific regulatory subunit protein p35, which is beneficial for neuronal development (Tsai et al. 1994; Chae et al. 1997). However, truncation of p35 and conversion to p25 (Patrick et al. 1999) is found in the forebrain of rats after focal cerebral ischemia and in AD patients, and these alterations are deleterious to the brain

Related Edges 5

• complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) increases act(p(HGNC:CDK5))
• p(HGNC:CDK5) increases complex(p(HGNC:CDK5), p(HGNC:CDK5R1))
• p(HGNC:CDK5R1) negativeCorrelation p(HBP:"CDK5R1 p25")
• p(HBP:"CDK5R1 p25") positiveCorrelation path(MESH:"Alzheimer Disease")
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"CDK5R1 p25")

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