g(HGNC:CHRNA7) association path(MESH:"Sensory Gating")

PubMed:19126755

In particular, the association of the alpha7 nAChR gene with a sensory gating deficit that is similar to attention deficits in patients with schizophrenia (157), and the degree of alpha4beta2 nAChR loss and altered alpha7 expresson correlate well with the magnitude of progressive cognitive decline in mild-to-moderate AD patients (46).

Related Edges 11

• bp(GO:cognition) positiveCorrelation p(HBP:"alpha-4 beta-2 nAChR")
• bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA7)
• p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition)
• p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease")
• p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease")
• p(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition)
• path(MESH:"Alzheimer Disease") negativeCorrelation p(HBP:"alpha-4 beta-2 nAChR")
• path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7)
• path(MESH:"Sensory Gating") association g(HGNC:CHRNA7)
• path(MESH:"Sensory Gating") association path(MESH:Schizophrenia)
• path(MESH:Schizophrenia) association path(MESH:"Sensory Gating")

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