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g(HGNC:CHRNA7)

Orthologies: 0 | Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
CHRNA7
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Identification and Characterization of a G Protein-binding Cluster in alpha7 Nicotinic Acetylcholine Receptors v1.0.0

In-Edges 2

composite(a(MESH:"HEK293 Cells"), g(HGNC:CHRNA7)) hasComponent g(HGNC:CHRNA7) View Subject | View Object

Appears in Networks:

path(MESH:"Sensory Gating") association g(HGNC:CHRNA7) View Subject | View Object

In particular, the association of the alpha7 nAChR gene with a sensory gating deficit that is similar to attention deficits in patients with schizophrenia (157), and the degree of alpha4beta2 nAChR loss and altered alpha7 expresson correlate well with the magnitude of progressive cognitive decline in mild-to-moderate AD patients (46). PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

Out-Edges 3

g(HGNC:CHRNA7) increases p(HGNC:CHRNA7) View Subject | View Object

Only two of these cell lines expressed alpha7 nAChRs: GH4C1 cells expressed substantially greater numbers of surface receptors than did SH-EP1 cells, which exhibited poor assembly efficiency. PubMed:19126755

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
GH4-C1 cell
Text Location
Review

g(HGNC:CHRNA7) association path(MESH:"Sensory Gating") View Subject | View Object

In particular, the association of the alpha7 nAChR gene with a sensory gating deficit that is similar to attention deficits in patients with schizophrenia (157), and the degree of alpha4beta2 nAChR loss and altered alpha7 expresson correlate well with the magnitude of progressive cognitive decline in mild-to-moderate AD patients (46). PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

g(HGNC:CHRNA7) hasVariant g(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) View Subject | View Object

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.