p(HBP:HBP00065) increases path(MESH:"Plaque, Amyloid")

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PubMed:21214928

There are reports showing that the protein and mRNA levels of KPI-containing APP isoforms are elevated in AD brain and associated with increased Ab deposition [9]; and prolonged activation of extrasynaptic NMDA receptor in neurons can shift APP expression from APP695 to KPI-containing APP isoforms, accompanied with increased production of Ab [10]

Related Edges 8

• a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00064)
• a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00065)
• a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(CHEBI:"amyloid-beta")
• p(HBP:HBP00064) increases path(MESH:"Plaque, Amyloid")
• p(HBP:HBP00065) positiveCorrelation path(MESH:"Alzheimer Disease")
• path(MESH:"Alzheimer Disease") positiveCorrelation r(HBP:HBP00064)
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:HBP00065)
• r(HBP:HBP00064) positiveCorrelation path(MESH:"Alzheimer Disease")

Confidence

Medium

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