a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(CHEBI:"amyloid-beta")

View Subject View Object

PubMed:21214928

There are reports showing that the protein and mRNA levels of KPI-containing APP isoforms are elevated in AD brain and associated with increased Ab deposition [9]; and prolonged activation of extrasynaptic NMDA receptor in neurons can shift APP expression from APP695 to KPI-containing APP isoforms, accompanied with increased production of Ab [10]

Related Edges 8

• a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00064)
• a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00065)
• p(HBP:HBP00064) increases path(MESH:"Plaque, Amyloid")
• p(HBP:HBP00065) increases path(MESH:"Plaque, Amyloid")
• p(HBP:HBP00065) positiveCorrelation path(MESH:"Alzheimer Disease")
• path(MESH:"Alzheimer Disease") positiveCorrelation r(HBP:HBP00064)
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:HBP00065)
• r(HBP:HBP00064) positiveCorrelation path(MESH:"Alzheimer Disease")

Confidence

Medium

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---