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Entity

Name
Receptors, N-Methyl-D-Aspartate
Namespace
mesh
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh-names.belns

Appears in Networks 10

In-Edges 8

complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") View Subject | View Object

On the other hand, stimulation of Gαq coupled muscarinic receptors generates intracellular second messengers that can facilitate N-methyl-D-aspartate (NMDA) currents PubMed:26813123

complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") View Subject | View Object

On the other hand, stimulation of Gαq coupled muscarinic receptors generates intracellular second messengers that can facilitate N-methyl-D-aspartate (NMDA) currents PubMed:26813123

complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") View Subject | View Object

On the other hand, stimulation of Gαq coupled muscarinic receptors generates intracellular second messengers that can facilitate N-methyl-D-aspartate (NMDA) currents PubMed:26813123

p(HBP:"projection domain") association a(MESH:"Receptors, N-Methyl-D-Aspartate") View Subject | View Object

In synapses, the projection domain of tau interacts with protein kinase Fyn (plays an important role during myelination [75]), postsynaptic density protein 95 (PSD-95) [76], and N-methyl-D-aspartate receptors (NMDAR). PubMed:26751493

path(MESH:"Alzheimer Disease") association a(MESH:"Receptors, N-Methyl-D-Aspartate") View Subject | View Object

PP2A enzymes can also associate with protein kinases that have been linked to AD, such as glycogen synthase kinase 3β (GSK3β) and cyclin-dependent kinase 5 (cdk5; Plattner et al.,2006), and neuronal receptors, e.g., the NMDA receptor (Chan and Sucher, 2001) and the metabotropic glutamate receptor 5 (Mao et al., 2005; Arif et al., 2014). PubMed:24653673

a(CHEBI:"glutamate(1-)") increases act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) View Subject | View Object

Glutamate induced stimulation of cerebellar granule cells via the N-methyl-D-aspartate (NMDA) receptor activate p65:p50 dimers and enhance transactivation of pro-apoptotic factors PubMed:25652642

Out-Edges 17

a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00064) View Subject | View Object

There are reports showing that the protein and mRNA levels of KPI-containing APP isoforms are elevated in AD brain and associated with increased Ab deposition [9]; and prolonged activation of extrasynaptic NMDA receptor in neurons can shift APP expression from APP695 to KPI-containing APP isoforms, accompanied with increased production of Ab [10] PubMed:21214928

Annotations
Confidence
Medium

a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00065) View Subject | View Object

There are reports showing that the protein and mRNA levels of KPI-containing APP isoforms are elevated in AD brain and associated with increased Ab deposition [9]; and prolonged activation of extrasynaptic NMDA receptor in neurons can shift APP expression from APP695 to KPI-containing APP isoforms, accompanied with increased production of Ab [10] PubMed:21214928

Annotations
Confidence
Medium

a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(CHEBI:"amyloid-beta") View Subject | View Object

There are reports showing that the protein and mRNA levels of KPI-containing APP isoforms are elevated in AD brain and associated with increased Ab deposition [9]; and prolonged activation of extrasynaptic NMDA receptor in neurons can shift APP expression from APP695 to KPI-containing APP isoforms, accompanied with increased production of Ab [10] PubMed:21214928

Annotations
Confidence
Medium

a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00064) View Subject | View Object

The levels of APP isoforms with a KPI domain seem to be elevated in patients with AD (Menendez- Gonzalez et al. 2005) and a splicing shift in neurons from APP695 to KPI-containing APP isoforms, along with increased Abeta generation, is observed when the NMDA receptor is activated (Bordji et al. 2010) PubMed:22122372

a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00065) View Subject | View Object

The levels of APP isoforms with a KPI domain seem to be elevated in patients with AD (Menendez- Gonzalez et al. 2005) and a splicing shift in neurons from APP695 to KPI-containing APP isoforms, along with increased Abeta generation, is observed when the NMDA receptor is activated (Bordji et al. 2010) PubMed:22122372

a(MESH:"Receptors, N-Methyl-D-Aspartate") decreases a(HBP:HBP00063) View Subject | View Object

The levels of APP isoforms with a KPI domain seem to be elevated in patients with AD (Menendez- Gonzalez et al. 2005) and a splicing shift in neurons from APP695 to KPI-containing APP isoforms, along with increased Abeta generation, is observed when the NMDA receptor is activated (Bordji et al. 2010) PubMed:22122372

a(MESH:"Receptors, N-Methyl-D-Aspartate") association p(HBP:"projection domain") View Subject | View Object

In synapses, the projection domain of tau interacts with protein kinase Fyn (plays an important role during myelination [75]), postsynaptic density protein 95 (PSD-95) [76], and N-methyl-D-aspartate receptors (NMDAR). PubMed:26751493

a(MESH:"Receptors, N-Methyl-D-Aspartate") increases act(p(HGNC:RAC1)) View Subject | View Object

CaMKs functionally link NMDA (N-methyl-d-aspartate) receptors to Rac1 activation via the phosphorylation of specific guanine nucleotide exchange factors (GEFs) such as Kalirin-7, TIAM1 and β-PIX PubMed:27796283

Appears in Networks:

a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HGNC:TIAM1, pmod(Ph)) View Subject | View Object

CaMKs functionally link NMDA (N-methyl-d-aspartate) receptors to Rac1 activation via the phosphorylation of specific guanine nucleotide exchange factors (GEFs) such as Kalirin-7, TIAM1 and β-PIX PubMed:27796283

Appears in Networks:

act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases p(HBP:"Tau epitope, AT8") View Subject | View Object

Hence, LTD-inducing NMDA receptor activation leads to an increase in tau phosphorylation at sites PHF-1, AT180, as well as AT8 and to a reduction at AT100. PubMed:22833681

Appears in Networks:
Annotations
Uberon
hippocampal formation

act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases a(HBP:"Tau epitope, PHF1") View Subject | View Object

Hence, LTD-inducing NMDA receptor activation leads to an increase in tau phosphorylation at sites PHF-1, AT180, as well as AT8 and to a reduction at AT100. PubMed:22833681

Appears in Networks:
Annotations
Uberon
hippocampal formation

act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases a(HBP:"Tau epitope, AT180") View Subject | View Object

Hence, LTD-inducing NMDA receptor activation leads to an increase in tau phosphorylation at sites PHF-1, AT180, as well as AT8 and to a reduction at AT100. PubMed:22833681

Appears in Networks:
Annotations
Uberon
hippocampal formation

act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) decreases a(HBP:"Tau epitope, AT100") View Subject | View Object

Hence, LTD-inducing NMDA receptor activation leads to an increase in tau phosphorylation at sites PHF-1, AT180, as well as AT8 and to a reduction at AT100. PubMed:22833681

Appears in Networks:
Annotations
Uberon
hippocampal formation

a(MESH:"Receptors, N-Methyl-D-Aspartate") association path(MESH:"Alzheimer Disease") View Subject | View Object

PP2A enzymes can also associate with protein kinases that have been linked to AD, such as glycogen synthase kinase 3β (GSK3β) and cyclin-dependent kinase 5 (cdk5; Plattner et al.,2006), and neuronal receptors, e.g., the NMDA receptor (Chan and Sucher, 2001) and the metabotropic glutamate receptor 5 (Mao et al., 2005; Arif et al., 2014). PubMed:24653673

a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates bp(GO:"calcium ion import") View Subject | View Object

The molecular mechanism underlying constitutive activation of NF-κB by glutamate-induced excitatory synaptic neurotransmission has been ascribed to NMDA receptor mediated Ca2+ influx and subsequent activation of CaMKII PubMed:28745240

a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates act(p(HGNC:CAMK2A)) View Subject | View Object

The molecular mechanism underlying constitutive activation of NF-κB by glutamate-induced excitatory synaptic neurotransmission has been ascribed to NMDA receptor mediated Ca2+ influx and subsequent activation of CaMKII PubMed:28745240

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.