Upload at 2019-02-27 16:23:15.838423
Sandra Spalek and Charles Tapley Hoyt
Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage from Shafiei et al., 2017
CC BY 4.0
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved
Number Nodes
Number Edges
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Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation v1.0.0 45%
Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. v1.0.0 40%
Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0 38%
Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways v1.0.1 37%
Tau oligomers and tau toxicity in neurodegenerative disease v1.0.0 37%
Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease v1.0.0 33%
Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity v1.0.0 32%
Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers v1.0.0 30%
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain v1.0.1 29%
Tau Modifications v1.9.5 29%

Sample Edges

a(CHEBI:dextran) association a(HBP:"Tau aggregates") View Subject | View Object

Evidence shows that tau aggregates colocalize with dextran and HeLa cells, hinting that internalized aggregates are transported in endosomal vesicles and passed through the endosomal pathway to lysosomes (Wu et al., 2013) PubMed:28420982

a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Compared to non-demented controls, AD brains exhibit up to 50% of neuronal loss in the cortex, exceeding the number of NFTs (Gómez-Isla et al., 1997) PubMed:28420982

Cerebral Cortex

Sample Nodes


In-Edges: 111 | Out-Edges: 35 | Explore Neighborhood | Download JSON


In-Edges: 112 | Out-Edges: 33 | Explore Neighborhood | Download JSON

path(MESH:"Alzheimer Disease")

In-Edges: 536 | Out-Edges: 704 | Classes: 5 | Explore Neighborhood | Download JSON


In-Edges: 56 | Out-Edges: 30 | Explore Neighborhood | Download JSON


In-Edges: 10 | Out-Edges: 65 | Explore Neighborhood | Download JSON


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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.