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Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways 1.0.1

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:23:06.802505
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
19
Number Edges
63
Number Components
2
Network Density
0.184210526315789
Average Degree
3.31578947368421
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Tau Modifications v1.9.5 42%
Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0 38%
Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0 37%
The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0 37%
Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation v1.0.0 36%
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies v1.0.0 26%
Alzheimer’s disease and the autophagic-lysosomal system v1.0.0 26%
Tau in physiology and pathology v1.0.0 21%
Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs) v1.0.1 21%
Interplay of pathogenic forms of human tau with different autophagic pathways v1.0.1 21%

Sample Edges

a(CHEBI:"cytochalasin D") decreases bp(GO:"actin filament polymerization") View Subject | View Object

Inhibition of actin polymerization with Cytochalasin D disrupts several clathrin-independent endocytic processes, including bulk endocytosis/ macropinocytosis (Mooren et al., 2012) PubMed:29590627

a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:"bulk synaptic vesicle endocytosis") View Subject | View Object

Inhibition of actin polymerization with Cytochalasin D disrupts several clathrin-independent endocytic processes, including bulk endocytosis/ macropinocytosis (Mooren et al., 2012) PubMed:29590627

a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:macropinocytosis) View Subject | View Object

Inhibition of actin polymerization with Cytochalasin D disrupts several clathrin-independent endocytic processes, including bulk endocytosis/ macropinocytosis (Mooren et al., 2012) PubMed:29590627

a(CHEBI:"cytochalasin D") decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) View Subject | View Object

Entry of monomeric tau was markedly reduced in the presence of 1 mM Cytochalasin D, as reflected in the 95% reduction in the number of monomeric tau-pHrodo-positive objects after 3-hr incubation in the presence of 1 mMCytochalasinD (Figure 5C) PubMed:29590627

a(CHEBI:"cytochalasin D") causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) View Subject | View Object

In contrast, disruption of actin polymerization with Cytochalasin D had little effect on the entry of aggregated tau (total fluorescent intensity and number of objects; Figures 5D–5F; Figure S5) PubMed:29590627

Sample Nodes

p(HGNC:MAPT)

In-Edges: 477 | Out-Edges: 480 | Classes: 11 | Children: 27 | Explore Neighborhood | Download JSON

p(HGNC:DNM1)

In-Edges: 2 | Out-Edges: 4 | Explore Neighborhood | Download JSON

a(HBP:"Tau aggregates")

In-Edges: 224 | Out-Edges: 71 | Children: 3 | Explore Neighborhood | Download JSON

bp(GO:endocytosis)

In-Edges: 25 | Out-Edges: 27 | Explore Neighborhood | Download JSON

a(GO:lysosome)

In-Edges: 24 | Out-Edges: 16 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.