The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
Heparin blocks Tau binding by masking HSPG binding sites on Tau, and sodium chlorate inhibits HSPG sulfation. PubMed:25887395
To test whether HSPGs also mediate BD Tau seeding, we titrated heparin and sodium chlorate, which inhibited seeding of all species (Fig. 8D). PubMed:25887395
Heparin blocks Tau binding by masking HSPG binding sites on Tau, and sodium chlorate inhibits HSPG sulfation. PubMed:25887395
To test whether HSPGs also mediate BD Tau seeding, we titrated heparin and sodium chlorate, which inhibited seeding of all species (Fig. 8D). PubMed:25887395
Whereas control brain homogenate exhibited mainly Tau monomer, the AD brain contained a range of Tau assemblies ranging from n = 1 to n > 20 (Fig. 7, A and B). PubMed:25887395
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.