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Network Catalog

Each curated network is backed by a BEL script. Below are options to summarize the networks' contents or explore them with an in-browser navigator.

Heme Curation 0.0.1-dev by Daniel Domingo-Fernández, et. al
763 nodes | 3004 edges | 46 citations | Public

Mechanistic knowledge surrounding heme

Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems 1.0.1 by Esther Wollert
27 nodes | 52 edges | 1 citation | Public

Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice 1.0.0 by Sandra Spalek
12 nodes | 27 edges | 1 citation | Public

Clinical presentation of a complex neurodevelopmental disorder caused by mutations in ADNP 1.0.0 by Esther Wollert
28 nodes | 27 edges | 1 citation | Public

The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse 1.0.0 by Sandra Spalek
26 nodes | 63 edges | 1 citation | Public

Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome 1.0.0 by Sandra Spalek
66 nodes | 183 edges | 1 citation | Public

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders 1.0.0 by Sandra Spalek
128 nodes | 347 edges | 1 citation | Public

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis 1.0.0 by Sandra Spalek
71 nodes | 147 edges | 1 citation | Public

Upstream regulators and downstream effectors of NF-κBinAlzheimer's disease 1.0.0 by Esther Wollert
96 nodes | 214 edges | 1 citation | Public

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease 1.0.0 by Esther Wollert
121 nodes | 245 edges | 1 citation | Public

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease 1.0.0 by Sandra Spalek
137 nodes | 300 edges | 1 citation | Public

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. 1.0.0 by Esther Wollert
20 nodes | 35 edges | 1 citation | Public

RelB/p50 complexes regulate cytokine-induced YKL-40 expression 1.0.0 by Sandra Spalek
36 nodes | 95 edges | 1 citation | Public

New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases 1.0.0 by Sandra Spalek
95 nodes | 180 edges | 1 citation | Public

Tau in physiology and pathology 1.0.0 by Sandra Spalek
169 nodes | 413 edges | 1 citation | Public

Alzheimer's disease pathological lesions activate the spleen tyrosine kinase. 1.0.0 by Esther Wollert
17 nodes | 50 edges | 1 citation | Public

Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes 1.0.0 by Sandra Spalek
48 nodes | 127 edges | 1 citation | Public

Caenorhabditis elegans models of tauopathy 1.0.0 by Sandra Spalek
113 nodes | 191 edges | 1 citation | Public

Screening of a neuronal cell model of Tau pathology for therapeutic compounds 1.0.0 by Esther Wollert
62 nodes | 105 edges | 1 citation | Public

The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* 1.0.0 by Sandra Spalek
50 nodes | 118 edges | 1 citation | Public

Inert and seed-competent tau monomers suggest structural origins of aggregation 1.0.0 by Esther Wollert
8 nodes | 11 edges | 1 citation | Public

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation 1.0.0 by Esther Wollert
11 nodes | 16 edges | 1 citation | Public

Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability 1.0.0 by Sandra Spalek
37 nodes | 54 edges | 1 citation | Public

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity 1.0.0 by Esther Wollert
28 nodes | 42 edges | 1 citation | Public

Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition 1.0.0 by Esther Wollert
13 nodes | 15 edges | 1 citation | Public

Molecular chaperones and proteostasis regulation during redox imbalance 1.0.0 by Esther Wollert
74 nodes | 100 edges | 1 citation | Public

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection 1.0.0 by Sandra Spalek
123 nodes | 226 edges | 1 citation | Public

Molecular Chaperone Functions in Protein Folding and Proteostasis 1.0.0 by Esther Wollert
63 nodes | 110 edges | 1 citation | Public

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease 1.0.0 by Sandra Spalek
180 nodes | 454 edges | 1 citation | Public

Alzheimer’s disease and the autophagic-lysosomal system 1.0.0 by Sandra Spalek
157 nodes | 343 edges | 1 citation | Public

Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity 1.0.0 by Esther Wollert
46 nodes | 78 edges | 1 citation | Public

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo 1.0.0 by Sandra Spalek
22 nodes | 60 edges | 1 citation | Public

PP2A and Alzheimer Disease 1.0.0 by Esther Wollert
47 nodes | 106 edges | 1 citation | Public

Axonal Transport, Tau Protein, and Neurodegeneration in Alzheimer’s Disease 1.0.0 by Esther Wollert
41 nodes | 59 edges | 1 citation | Public

Protein phosphatase 2A dysfunction in Alzheimer’s disease 1.0.0 by Sandra Spalek
122 nodes | 411 edges | 1 citation | Public

Assembly and structure of protein phosphatase 2A 1.0.0 by Sandra Spalek
62 nodes | 165 edges | 1 citation | Public

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer 1.0.0 by Esther Wollert
84 nodes | 141 edges | 1 citation | Public

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation 1.0.0 by Sandra Spalek
143 nodes | 316 edges | 1 citation | Public

Silencing of PMT expression caused a surge of anatabine accumulation in tobacco 1.0.0 by Sandra Spalek
13 nodes | 21 edges | 1 citation | Public

Chronic Anatabine Treatment Reduces Alzheimer ’ s Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD 1.0.0 by Esther Wollert
20 nodes | 37 edges | 1 citation | Public

Discriminative Stimulus Properties of S(−)-Nicotine: “A Drug for All Seasons 1.0.0 by Sandra Spalek
61 nodes | 83 edges | 1 citation | Public

Anatabine Attenuates Tau Phosphorylation and Oligomerization in P301S Tau Transgenic Mice 1.0.0 by Sandra Spalek
18 nodes | 29 edges | 1 citation | Public

Anatabine lowers Alzheimer's Aβ production in vitro and in vivo 1.0.0 by Sandra Spalek
20 nodes | 37 edges | 1 citation | Public

Anatabine ameliorates experimental autoimmune thyroiditis. 1.0.0 by Esther Wollert
15 nodes | 18 edges | 1 citation | Public

Amyloid-Binding Alcohol Dehydrogenase (ABAD) Inhibitors for the Treatment of Alzheimer’s Disease 1.0.0 by Esther Wollert
78 nodes | 113 edges | 1 citation | Public

Inflammasome Involvement in Alzheimer’s Disease 1.0.0 by Esther Wollert
46 nodes | 88 edges | 1 citation | Public

The role of inflammasome in Alzheimer’s disease 1.0.3 by Sandra Spalek
70 nodes | 166 edges | 1 citation | Public

Activation and regulation of the inflammasomes 1.0.0 by Esther Wollert
124 nodes | 185 edges | 1 citation | Public

Inflammasome activation and innate immunity in Alzheimer’s disease 1.0.2 by Sandra Spalek
24 nodes | 41 edges | 1 citation | Public

Tau Modifications 1.9.5 by Kristian Kolpeja
949 nodes | 2408 edges | 183 citations | Public

Tau Modifications Sections of NESTOR

Tau Effect on Mitochondria 1.0.3 by Kristian Kolpeja
36 nodes | 97 edges | 1 citation | Public

Tau and mitochondria section of NESTOR

TAU and Interaction Partners 1.2.5 by Kristian Kolpeja
159 nodes | 453 edges | 29 citations | Public

TAU Interactions Section of NESTOR

Tau Biochemistry 1.2.5 by Kristian Kolpeja
92 nodes | 174 edges | 6 citations | Public

Tau Biochemistry Section of NESTOR

Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology 1.0.0 by Lingling Xu
28 nodes | 38 edges | 1 citation | Public

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy 1.0.1 by Sandra Spalek
149 nodes | 279 edges | 1 citation | Public

Tau oligomers and tau toxicity in neurodegenerative disease 1.0.0 by Sandra Spalek
30 nodes | 63 edges | 1 citation | Public

Tau oligomers and tau toxicity in neurodegenerative disease by Ward et al., 2012

Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. 1.0.0 by Rana Aldisi
15 nodes | 31 edges | 1 citation | Public

Clearance systems in the brain-implications for Alzheimer disease. 1.0.1 by Lingling Xu
83 nodes | 123 edges | 1 citation | Public

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain 1.0.1 by Esther Wollert
17 nodes | 31 edges | 1 citation | Public

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies 1.0.0 by Kristian Kolpeja
107 nodes | 203 edges | 1 citation | Public

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies 1.0.0 by Esther Wollert
95 nodes | 191 edges | 1 citation | Public

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage 1.0.0 by Sandra Spalek and Charles Tapley Hoyt
69 nodes | 134 edges | 1 citation | Public

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage from Shafiei et al., 2017

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs) 1.0.1 by Sandra Spalek
28 nodes | 63 edges | 1 citation | Public

Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β. 1.0.0 by Lingling Xu
35 nodes | 78 edges | 1 citation | Public

Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro 1.0.0 by Rana Aldisi
11 nodes | 34 edges | 1 citation | Public

This file encodes the article Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro by Nobuhara et. al. 2017

Tau protein aggregation is associated with cellular senescence in the brain 1.0.0 by Sandra Spalek
77 nodes | 152 edges | 1 citation | Public

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies 1.0.0 by Sandra Spalek
118 nodes | 226 edges | 1 citation | Public

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading 1.0.0 by Lingling Xu
26 nodes | 36 edges | 1 citation | Public

Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. 1.0.0 by Esther Wollert
60 nodes | 95 edges | 1 citation | Public

Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. 1.0.0 by Lingling Xu
21 nodes | 42 edges | 1 citation | Public

Anti-aggregant tau mutant promotes neurogenesis 1.0.0 by Sandra Spalek
20 nodes | 53 edges | 1 citation | Public

Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers 1.0.0 by Rana Aldisi
24 nodes | 77 edges | 1 citation | Public

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways 1.0.1 by Sandra Spalek
19 nodes | 63 edges | 1 citation | Public

Identification of the Tau phosphorylation pattern that drives its aggregation 1.0.0 by Kristian Kolpeja
13 nodes | 22 edges | 1 citation | Public

Adenosine A1 receptor antagonist 64627 alleviates axonopathy caused by human Tau ΔK280 1.0.0 by Sandra Spalek
45 nodes | 104 edges | 1 citation | Public

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers 1.0.0 by Rana Aldisi
23 nodes | 50 edges | 1 citation | Public

This document contains the bel code for the Article Alzheimer’s disease-type neuronal tau hyperphosphorylation induced by Abeta oligomers by De Felice et al

Analysis of Isoform-specific Tau Aggregates Suggests a Common Toxic Mechanism Involving Similar Pathological Conformations and Axonal Transport Inhibition 1.0.1 by Sandra Spalek
38 nodes | 191 edges | 1 citation | Public

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease 1.0.0 by Rana Aldisi
114 nodes | 276 edges | 1 citation | Public

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau 1.0.0 by Sandra Spalek
57 nodes | 116 edges | 1 citation | Public

Interplay of pathogenic forms of human tau with different autophagic pathways 1.0.1 by Sandra Spalek
60 nodes | 141 edges | 1 citation | Public

Progress and Developments in Tau Aggregation Inhibitors for Alzheimer Disease 0.1.0 by Charles Tapley Hoyt
23 nodes | 23 edges | 1 citation | Public

A small assortment of academic articles describing quantitatively described interactions between the MAPT (Tau) protein and small molecules

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing 1.0.0 by Esther Wollert, et. al
192 nodes | 366 edges | 1 citation | Public

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations 1.0.0 by Sandra Spalek
36 nodes | 88 edges | 1 citation | Public

Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5 1.0.0 by Sandra Spalek
20 nodes | 70 edges | 1 citation | Public

In Vivo and In Vitro Characterization of Antalarmin, a Nonpeptide Corticotropin-Releasing Hormone (CRH) Receptor Antagonist: Suppression of Pituitary ACTH Release and Peripheral Inflammation 1.0.0 by Kristian Kolpeja
5 nodes | 9 edges | 1 citation | Public

The effect of CRH and its inhibitor, antalarmin, on in vitro growth of preantral mouse follicles, early embryo development, and steroidogenesis. 1.0.0 by Lingling Xu
8 nodes | 14 edges | 1 citation | Public

Corticotropin-releasing factor regulates caspase-3 and may protect developing zebrafish from stress-induced apoptosis 1.0.0 by Lingling Xu
7 nodes | 14 edges | 1 citation | Public

Structural and functional properties of prefibrillar α-synuclein oligomers 1.0.0 by Esther Wollert and Charles Tapley Hoyt
13 nodes | 19 edges | 1 citation | Public

Alpha-synuclein oligomers: a new hope 1.0.0 by Esther Wollert
48 nodes | 64 edges | 1 citation | Public

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways 1.0.0 by Sandra Spalek
274 nodes | 533 edges | 1 citation | Public

The Biology of Proteostasis in Aging and Disease 1.0.0 by Esther Wollert
94 nodes | 160 edges | 1 citation | Public

Perilous journey: a tour of the ubiquitin–proteasome system 1.0.0 by Sandra Spalek
56 nodes | 92 edges | 1 citation | Public

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg 1.0.0 by Sandra Spalek
272 nodes | 488 edges | 1 citation | Public

A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease. 1.0.0 by Esther Wollert
29 nodes | 51 edges | 1 citation | Public

Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine 1.0.0 by Sandra Spalek
24 nodes | 81 edges | 1 citation | Public

Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation 1.0.0 by Sandra Spalek
25 nodes | 77 edges | 1 citation | Public

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. 1.0.0 by Lingling Xu
94 nodes | 173 edges | 1 citation | Public

Naturally-expressed nicotinic acetylcholine receptor subtypes 1.0.0 by Esther Wollert
42 nodes | 67 edges | 1 citation | Public

Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype 1.0.0 by Esther Wollert
8 nodes | 11 edges | 1 citation | Public

Chaperoning α7 neuronal nicotinic acetylcholine receptors 1.0.0 by Esther Wollert
75 nodes | 111 edges | 1 citation | Public

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system 1.0.0 by Rana Aldisi
114 nodes | 210 edges | 1 citation | Public

This document contains the curation of the review article Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system by Taly et al. 2009

Selective activation of α7 nicotinic acetylcholine receptor by PHA-543613 improves Aβ25-35-mediated cognitive deficits in mice 1.0.0 by Rana Aldisi
11 nodes | 35 edges | 1 citation | Public

The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice 1.0.0 by Sandra Spalek
13 nodes | 13 edges | 1 citation | Public

B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor 1.0.0 by Sandra Spalek
12 nodes | 19 edges | 1 citation | Public

Nicotinic Receptor Abnormalities of Alzheimer’s Disease: Therapeutic Implications 1.0.0 by Sandra Spalek
59 nodes | 118 edges | 1 citation | Public

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications 1.0.0 by Rana Aldisi
176 nodes | 307 edges | 1 citation | Public

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses 1.0.0 by Sandra Spalek
106 nodes | 237 edges | 1 citation | Public

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain 1.0.0 by Sandra Spalek
62 nodes | 112 edges | 1 citation | Public

Nuclear receptors as therapeutic targets for Alzheimer's disease. 1.0.0 by Esther Wollert
83 nodes | 169 edges | 1 citation | Public

Nicotinic α4β2 acetylcholine receptors and cognitive function in Parkinson's disease 1.0.0 by Lingling Xu
9 nodes | 21 edges | 1 citation | Public

A role for b2* nicotinic receptors in a model of local amyloid pathology induced in dentate gyrus 1.0.0 by Sandra Spalek
21 nodes | 40 edges | 1 citation | Public

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment 1.0.1 by Sandra Spalek
124 nodes | 246 edges | 1 citation | Public

Identification and Characterization of a G Protein-binding Cluster in alpha7 Nicotinic Acetylcholine Receptors 1.0.0 by Rana Aldisi
40 nodes | 87 edges | 1 citation | Public

M1 muscarinic acetylcholine receptor in Alzheimer’s disease 1.0.0 by Rana Aldisi
135 nodes | 225 edges | 1 citation | Public

This file encodes the article M1 muscarinic acetylcholine receptor in Alzheimer’s disease by Jiang et al, 2014

Interplay of neurotransmitters in Alzheimer's disease 1.0.0 by Rana Aldisi
40 nodes | 80 edges | 1 citation | Public

Alzheimer's Disease: Targeting the Cholinergic System 1.0.0 by Sandra Spalek
159 nodes | 298 edges | 1 citation | Public

The CRF1 receptor antagonist, antalarmin, reverses isolation-induced up-regulation of dopamine D2 receptors in the amygdala and nucleus accumbens of fawn-hooded rats 1.0.0 by Lingling Xu
15 nodes | 28 edges | 1 citation | Public

Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine 1.0.1 by Esther Wollert
17 nodes | 21 edges | 1 citation | Public

Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System 1.0.0 by Esther Wollert and Charles Tapley Hoyt
86 nodes | 194 edges | 1 citation | Public

Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia. 1.0.0 by Rana Aldisi
97 nodes | 207 edges | 1 citation | Public

This file encodes the article Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer’s disease and schizophrenia by Choi et al, 2014

The Nicotinic Acetylcholine Receptor: The Founding Father of the Pentameric Ligand-gated Ion Channel Superfamily 1.0.1 by Lingling Xu
54 nodes | 60 edges | 1 citation | Public

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. 1.0.0 by Rana Aldisi
228 nodes | 545 edges | 1 citation | Public

albuquerque2009 1.0.0 by Rana Aldisi
267 nodes | 495 edges | 1 citation | Public

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Proteolytic processing of Alzeimer's beta-amyloid precursor protein 1.0.1 by Sandra Spalek
135 nodes | 226 edges | 1 citation | Public

APP processing in Alzheimer's disease 1.0.1 by Sandra Spalek
147 nodes | 265 edges | 1 citation | Public

APP processing in Alzheimer's disease

Effects of peptides derived from BACE1 catalytic domain on APP processing 1.0.0 by Rana Aldisi
10 nodes | 30 edges | 1 citation | Public

Amyloid Precursor Protein Trafficking, Processing, and Function 1.0.0 by Esther Wollert
40 nodes | 48 edges | 1 citation | Public

Amyloid Precursor Protein Trafficking, Processing, and Function by Thinakaran, et al., 2008