The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
Aβ synaptoxicity is Dkk1-dependent12,24 and also appears to be APP-dependent25. PubMed:30232325
The Wnt-PCP signalling pathway acts through RhoA and ROCK26, and can be inhibited pharmacologically, for example, with fasudil24, a ROCK inhibitor that is in clinical use for the treatment of cerebral vasospasm. PubMed:30232325
Fasudil also reversed the stimulatory effect of Vangl2 and Dkk1 on Aβ production in the same cells as determined by ELISA based quantification of Aβ1–40 levels in the paired culture media from the same experiments (Fig. 3d). PubMed:30232325
Animals receiving fasudil had significantly lower soluble Aβ1–40 levels than controls (Fig. 4b). PubMed:30232325
APP has previously been shown to interact with Vangl2, a Wnt-PCP-specific co-receptor protein, and independently has been shown to bind LRP6, a receptor component of the Wnt-β-catenin pathway21. PubMed:30232325
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.