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bp(GO:"Wnt signaling pathway, planar cell polarity pathway")

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Entity

Name
Wnt signaling pathway, planar cell polarity pathway
Namespace
go
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/go-names.belns

Appears in Networks 1

A role for APP in Wnt signalling links synapse loss with β-amyloid production. v1.0.0

In-Edges 7

a(CHEBI:"fasudil hydrochloride") decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") View Subject | View Object

The Wnt-PCP signalling pathway acts through RhoA and ROCK26, and can be inhibited pharmacologically, for example, with fasudil24, a ROCK inhibitor that is in clinical use for the treatment of cerebral vasospasm. PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

bp(GO:"amyloid-beta formation") positiveCorrelation bp(GO:"Wnt signaling pathway, planar cell polarity pathway") View Subject | View Object

Comparison of signalling activity and Aβ production under each of the different conditions showed clearly that Aβ production was negatively correlated with Wnt-β-catenin signalling activity (Fig. 2d) and positively correlated with Wnt-PCP signalling (Fig. 2e). PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

p(HGNC:VANGL2) association bp(GO:"Wnt signaling pathway, planar cell polarity pathway") View Subject | View Object

APP has previously been shown to interact with Vangl2, a Wnt-PCP-specific co-receptor protein, and independently has been shown to bind LRP6, a receptor component of the Wnt-β-catenin pathway21. PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

act(p(HGNC:DKK1)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") View Subject | View Object

In contrast, the stimulatory effects of Dkk1 on WntPCP signalling induced by Wnt5a were enhanced by APP overexpression, decreasing the EC50 of Dkk1 to 599ng/ mL from 1405ng/mL (Fig. 2g). PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

composite(p(HGNC:APP), p(HGNC:LRP6)) decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") View Subject | View Object

Conversely, the ability of APP to potentiate Wnt-PCP signalling in response to Wnt5a was enhanced by Vangl2 and attenuated by LRP6 (Fig. 1h). PubMed:30232325

Appears in Networks:
Annotations
Confidence
Medium

composite(p(HGNC:APP), p(HGNC:VANGL2)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") View Subject | View Object

Conversely, the ability of APP to potentiate Wnt-PCP signalling in response to Wnt5a was enhanced by Vangl2 and attenuated by LRP6 (Fig. 1h). PubMed:30232325

Appears in Networks:
Annotations
Confidence
Medium

act(p(HGNC:WNT5A)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") View Subject | View Object

APP did though potentiate both Wnt3a-driven Wnt-β-catenin signalling and Wnt5a-driven Wnt-PCP signalling. PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

Out-Edges 3

bp(GO:"Wnt signaling pathway, planar cell polarity pathway") increases a(CHEBI:"amyloid-beta") View Subject | View Object

In cells expressing either wild-type or Swedish APP, the amount of Aβ produced was reduced in cells stimulated with Wnt3a, which promotes Wnt-βcatenin signalling, whereas Aβ production was enhanced in cells stimulated with Wnt5a, which promotes Wnt-PCP signalling (Fig. 2c). PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

bp(GO:"Wnt signaling pathway, planar cell polarity pathway") positiveCorrelation bp(GO:"amyloid-beta formation") View Subject | View Object

Comparison of signalling activity and Aβ production under each of the different conditions showed clearly that Aβ production was negatively correlated with Wnt-β-catenin signalling activity (Fig. 2d) and positively correlated with Wnt-PCP signalling (Fig. 2e). PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

bp(GO:"Wnt signaling pathway, planar cell polarity pathway") association p(HGNC:VANGL2) View Subject | View Object

APP has previously been shown to interact with Vangl2, a Wnt-PCP-specific co-receptor protein, and independently has been shown to bind LRP6, a receptor component of the Wnt-β-catenin pathway21. PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.