1. Catalog
  2. Nodes
  3. a(CHEBI:"fasudil hydrochloride")

a(CHEBI:"fasudil hydrochloride")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
fasudil hydrochloride
Namespace
chebi
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/chebi-names.belns

Appears in Networks 1

A role for APP in Wnt signalling links synapse loss with β-amyloid production. v1.0.0

In-Edges 1

composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) hasComponent a(CHEBI:"fasudil hydrochloride") View Subject | View Object

Appears in Networks:

Out-Edges 3

a(CHEBI:"fasudil hydrochloride") decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") View Subject | View Object

The Wnt-PCP signalling pathway acts through RhoA and ROCK26, and can be inhibited pharmacologically, for example, with fasudil24, a ROCK inhibitor that is in clinical use for the treatment of cerebral vasospasm. PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:"fasudil hydrochloride") decreases a(CHEBI:"amyloid-beta polypeptide 40") View Subject | View Object

Fasudil also reversed the stimulatory effect of Vangl2 and Dkk1 on Aβ production in the same cells as determined by ELISA based quantification of Aβ1–40 levels in the paired culture media from the same experiments (Fig. 3d). PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:"fasudil hydrochloride") decreases a(CHEBI:"amyloid-beta polypeptide 40") View Subject | View Object

Animals receiving fasudil had significantly lower soluble Aβ1–40 levels than controls (Fig. 4b). PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.