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  3. composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1))

composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 1

A role for APP in Wnt signalling links synapse loss with β-amyloid production. v1.0.0

In-Edges 0

Out-Edges 4

composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) hasComponent a(CHEBI:"fasudil hydrochloride") View Subject | View Object

Appears in Networks:

composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) hasComponent p(HGNC:DKK1) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) causesNoChange a(MESH:"Dendritic Spines") View Subject | View Object

Dkk1 resulted in substantial loss of dendritic spines, which was blocked by 10µM fasudil treatment (Fig. 3e, f). PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) causesNoChange a(CHEBI:"amyloid-beta") View Subject | View Object

Notably, in parallel with the protective effect of fasudil on synapses (Fig. 3e, f), treatment with fasudil reversed the stimulatory effects of Dkk1 on Aβ production (Fig. 3g). PubMed:30232325

Appears in Networks:
Annotations
Confidence
Medium

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.