1. Catalog
  2. Networks
  3. The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* 1.0.0

Compilation Biogrammar
Explore Query

Provenance

Upload
charles.hoyt@scai.fraunhofer.de at 2019-03-15 15:44:09.545322
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
50
Number Edges
118
Number Components
1
Network Density
0.0481632653061225
Average Degree
2.36
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Tau Modifications v1.9.5 46%
Anatabine Attenuates Tau Phosphorylation and Oligomerization in P301S Tau Transgenic Mice v1.0.0 44%
Alzheimer's disease pathological lesions activate the spleen tyrosine kinase. v1.0.0 41%
Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0 40%
Effects of peptides derived from BACE1 catalytic domain on APP processing v1.0.0 30%
Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. v1.0.0 25%
Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β. v1.0.0 23%
Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0 20%
Identification of a novel aspartic protease (Asp 2) as beta-secretase v1.0.0 20%
Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5 v1.0.0 20%

Sample Edges

p(HGNC:CREB1) hasVariant p(HGNC:CREB1, pmod(Ph)) View Subject | View Object

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(Ph, Ser, 202)) View Subject | View Object

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(Ph, Ser, 396)) View Subject | View Object

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(Ph, Ser, 404)) View Subject | View Object

p(HGNC:GSK3B) hasVariant p(HGNC:GSK3B, pmod(Ph, Ser, 9)) View Subject | View Object

Sample Nodes

a(CHEBI:"amyloid-beta")

In-Edges: 423 | Out-Edges: 245 | Children: 5 | Explore Neighborhood | Download JSON

a(CHEBI:"amyloid-beta polypeptide 40")

In-Edges: 23 | Out-Edges: 5 | Classes: 1 | Explore Neighborhood | Download JSON

p(HGNC:APP)

In-Edges: 106 | Out-Edges: 69 | Explore Neighborhood | Download JSON

p(HGNC:BACE1)

In-Edges: 65 | Out-Edges: 39 | Explore Neighborhood | Download JSON

p(HBP:"sAPP-beta")

In-Edges: 10 | Out-Edges: 1 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.