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Appears in Networks 5

In-Edges 10

a(PUBCHEM:11249342) decreases p(HBP:"sAPP-beta") View Subject | View Object

Specifically, Posiphen lowered sAPPa and sAPPb levels by 59.9% and 57.7%, respectively, assessed by the AlpaLisa assay, and by 34.1% and 34%, respectively, assessed by the MSD assay, in accordance with Posiphen’s proposed mechanism of action to inhibit APP expression. PubMed:22791904

a(CHEBI:Anatabine) decreases sec(p(HBP:"sAPP-beta")) View Subject | View Object

We then tested the impact of anatabine on sAPPα and sAPPβ production using 7W CHO cells and observed that anatabine inhibits sAPPβ secretion without impacting sAPPα suggesting that anatabine is preventing the β-cleavage of APP (Fig. 4). PubMed:21958873

Annotations
Experimental Factor Ontology (EFO)
CHO cell

a(CHEBI:nicotine) causesNoChange sec(p(HBP:"sAPP-beta")) View Subject | View Object

Nicotine does not appear to affect sAPPβ and sAPPα secretion in 7W CHO contrary to anatabine (Fig. 4) PubMed:21958873

Annotations
Experimental Factor Ontology (EFO)
CHO cell

a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases sec(p(HBP:"sAPP-beta")) View Subject | View Object

We found that, like (-)-nilvadipine, Syk inhibition with the selective Syk inhibitor BAY61-3606 resulted in decreased sAPPβ secretion, BACE-1 mRNA, and BACE-1 protein expression (data not shown). PubMed:25331948

a(CHEBI:Nilvadipine) decreases sec(p(HBP:"sAPP-beta")) View Subject | View Object

We have previously shown that racemic nilvadipine affects the β-cleavage of APP and reduces sAPPβ secretion PubMed:25331948

a(CHEBI:Nilvadipine) decreases sec(p(HBP:"sAPP-beta")) View Subject | View Object

We found that, like (-)-nilvadipine, Syk inhibition with the selective Syk inhibitor BAY61-3606 resulted in decreased sAPPβ secretion, BACE-1 mRNA, and BACE-1 protein expression (data not shown). PubMed:25331948

act(p(HGNC:SYK)) increases sec(p(HBP:"sAPP-beta")) View Subject | View Object

We found that, like (-)-nilvadipine, Syk inhibition with the selective Syk inhibitor BAY61-3606 resulted in decreased sAPPβ secretion, BACE-1 mRNA, and BACE-1 protein expression (data not shown). PubMed:25331948

p(HGNC:SYK) regulates p(HBP:"sAPP-beta") View Subject | View Object

Dystrophic neurites are characterized by an accumula- tion of BACE-1 and sAPP β [31] and our previous work [28] has shown that Syk regulates BACE-1 expression and sAPP β levels suggesting that Syk upregulation in dystrophic neurites could contribute to the accumulation of BACE-1 and sAPP β . PubMed:28877763

act(complex(GO:"NF-kappaB complex")) decreases p(HBP:"sAPP-beta") View Subject | View Object

Under physiological conditions activation of NF-κB by endogenous Aβ reduces βAPP, BACE1 and the γ-secretase activity, thereby lowering Aβ processing and facilitating Aβ homeostasis PubMed:25652642

act(complex(GO:"NF-kappaB complex")) positiveCorrelation p(HBP:"sAPP-beta") View Subject | View Object

However in AD, exposure to high Aβ concentrations upregulates NF-κB activation increasing βAPP and Aβ processing, precipitating a feed-back loop that favor exacerbated Aβ production PubMed:25652642

Out-Edges 1

p(HBP:"sAPP-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex")) View Subject | View Object

However in AD, exposure to high Aβ concentrations upregulates NF-κB activation increasing βAPP and Aβ processing, precipitating a feed-back loop that favor exacerbated Aβ production PubMed:25652642

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.