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Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-b peptide and s levels: target engagement, tolerability and pharmacokinetics in humans 0.1.0

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:11:44.456398
Authors
Lingling Xu
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved
Number Nodes
11
Number Edges
13
Number Components
1
Network Density
0.118181818181818
Average Degree
1.18181818181818
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Nuclear receptors as therapeutic targets for Alzheimer's disease. v1.0.0 27%
Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0 27%
Heme Curation v0.0.1-dev 27%
Inflammasome Involvement in Alzheimer’s Disease v1.0.0 18%
The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0 18%
APP processing in Alzheimer's disease v1.0.1 18%
Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1 18%
M1 muscarinic acetylcholine receptor in Alzheimer’s disease v1.0.0 18%
Tau in physiology and pathology v1.0.0 18%
Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0 18%

Sample Edges

a(PUBCHEM:11249342) increases path(MESH:Nausea) View Subject | View Object

A 160 mg dose was associated with an increased incidence of nausea and vomiting (four subjects were nauseous and three vomited) PubMed:22791904

a(PUBCHEM:11249342) causesNoChange path(MESH:Nausea) View Subject | View Object

Posiphen 80 mg was determined as the no observed adverse effect level (table 1). PubMed:22791904

a(PUBCHEM:11249342) increases path(MESH:Vomiting) View Subject | View Object

A 160 mg dose was associated with an increased incidence of nausea and vomiting (four subjects were nauseous and three vomited) PubMed:22791904

a(PUBCHEM:11249342) causesNoChange path(MESH:Vomiting) View Subject | View Object

Posiphen 80 mg was determined as the no observed adverse effect level (table 1). PubMed:22791904

a(PUBCHEM:11249342) decreases p(HBP:"sAPP-alpha") View Subject | View Object

Specifically, Posiphen lowered sAPPa and sAPPb levels by 59.9% and 57.7%, respectively, assessed by the AlpaLisa assay, and by 34.1% and 34%, respectively, assessed by the MSD assay, in accordance with Posiphen’s proposed mechanism of action to inhibit APP expression. PubMed:22791904

Sample Nodes

a(PUBCHEM:11249342)

In-Edges: 0 | Out-Edges: 12 | Explore Neighborhood | Download JSON

p(HBP:"sAPP-alpha")

In-Edges: 3 | Out-Edges: 2 | Explore Neighborhood | Download JSON

p(HBP:"sAPP-beta")

In-Edges: 10 | Out-Edges: 1 | Explore Neighborhood | Download JSON

p(HGNC:C3)

In-Edges: 5 | Out-Edges: 0 | Explore Neighborhood | Download JSON

p(HGNC:CCL2)

In-Edges: 3 | Out-Edges: 3 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.