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Biogrammar Summary of Interplay of neurotransmitters in Alzheimer's disease 1.0.0

Table of Contents

  1. Unstable Pairs
  2. Causal Pathologies

Unstable Pairs 1

Chaotic Pairs
Nodes that mutually increase each other, such as when both A increases B and B increases A.
Dampened Pairs
Nodes that mutually decrease each other, such as when both A decreases B and B decreases A.

While neither chaotic nor dampened pairs are biologically invalid, they require additional context to understand their regulation.

Type Node A Node B
Chaotic a(CHEBI:acetylcholine) complex(a(CHEBI:acetylcholine), p(MESH:D011950))

Causal Pathologies 2

Pathologies are more dogmatically the result of molecular and physical processes, and do not necessarily make sense as the subject of causal statements.

Source Relation Target
path(MESH:D000544) decreases complex(a(CHEBI:"magnesium(2+)"), p(GFAM:"Glutamate ionotropic receptor NMDA type subunits"))
path(MESH:D000544) decreases p(HGNC:CHAT)

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.