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The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse 1.0.0

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Provenance

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charles.hoyt@scai.fraunhofer.de at 2019-05-15 22:27:12.716345
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
26
Number Edges
63
Number Components
1
Network Density
0.0969230769230769
Average Degree
2.42307692307692
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome v1.0.0 35%
Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice v1.0.0 33%
Tau Modifications v1.9.5 15%
Tau in physiology and pathology v1.0.0 15%
mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0 15%
Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0 12%
Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia. v1.0.0 8%
Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1 8%
Nuclear receptors as therapeutic targets for Alzheimer's disease. v1.0.0 8%
Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0 8%

Sample Edges

p(HGNC:ADNP) hasVariant p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) View Subject | View Object

composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) hasComponent a(PUBCHEM:9832404) View Subject | View Object

composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) hasComponent p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) View Subject | View Object

a(CHEBI:"Evans blue") causesNoChange tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) View Subject | View Object

Further results showed no significant brain penetration of Evans blue ( < 0.1 ng/ml, which was the limit of detection), and no difference between chlorobutanol and saline. PubMed:30664622

a(CHEBI:"Evans blue") increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(GO:"cell periphery")) View Subject | View Object

Representative pictures show penetration of the Evans blue dye in the periphery (Fig. 1d), but not in the brain (Fig. 1e), with brain concentration values < 0.03 ng/ml (Supplemental Fig. S1) PubMed:30664622

Sample Nodes

bp(GO:memory)

In-Edges: 112 | Out-Edges: 33 | Explore Neighborhood | Download JSON

bp(GO:behavior)

In-Edges: 11 | Out-Edges: 3 | Explore Neighborhood | Download JSON

a(GO:"glutamatergic synapse")

In-Edges: 4 | Out-Edges: 2 | Explore Neighborhood | Download JSON

p(HGNC:SLC17A7)

In-Edges: 8 | Out-Edges: 3 | Explore Neighborhood | Download JSON

a(GO:"dendritic spine")

In-Edges: 23 | Out-Edges: 4 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.