Upload at 2019-05-15 22:27:13.462908
Sandra Spalek
CC BY 4.0
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0 33%
The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse v1.0.0 33%
Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome v1.0.0 33%
Heme Curation v0.0.1-dev 8%
The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0 8%
Alpha-synuclein oligomers: a new hope v1.0.0 8%
Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5 v1.0.0 8%
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0 8%
Adenosine A1 receptor antagonist 64627 alleviates axonopathy caused by human Tau ΔK280 v1.0.0 8%
Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies v1.0.0 8%

Sample Edges

a(PUBCHEM:9832404) increases complex(a(GO:microtubule), p(HGNC:ADNP)) View Subject | View Object

NAP has been shown to ameliorate Adnp deficiencies in the haploinsufficient mouse model [25], mechanistically by enhancing ADNP association with its microtubule and autophagy targets PubMed:30008470

a(PUBCHEM:9832404) increases act(p(HGNC:ADNP)) View Subject | View Object

These results indicate that restoration of ADNP function by NAP administration rescues the wild type phenotype of the Adnp+/− mice, by reversing the abnormal increase in alcohol intake seen in Adnp haploinsufficient female mice PubMed:30008470


Sample Nodes


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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.