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mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders 1.0.0

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Provenance

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charles.hoyt@scai.fraunhofer.de at 2019-05-15 22:27:09.677860
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
128
Number Edges
347
Number Components
2
Network Density
0.0213459645669291
Average Degree
2.7109375
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease v1.0.0 50%
Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0 38%
Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice v1.0.0 33%
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro v1.0.0 27%
Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation v1.0.0 27%
Anti-aggregant tau mutant promotes neurogenesis v1.0.0 25%
Alzheimer's disease pathological lesions activate the spleen tyrosine kinase. v1.0.0 24%
Structural and functional properties of prefibrillar α-synuclein oligomers v1.0.0 23%
Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers v1.0.0 22%
Alzheimer’s disease and the autophagic-lysosomal system v1.0.0 21%

Sample Edges

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) View Subject | View Object

p(FPLX:AKT) hasVariant p(FPLX:AKT, pmod(Ph)) View Subject | View Object

p(HGNC:SNCA) hasVariant p(HGNC:SNCA, var("?")) View Subject | View Object

p(HGNC:BECN1) hasVariant p(HGNC:BECN1, pmod(Ph)) View Subject | View Object

p(MGI:Mapt) hasVariant p(MGI:Mapt, pmod(Ph)) View Subject | View Object

Sample Nodes

a(CHEBI:"amyloid-beta")

In-Edges: 423 | Out-Edges: 245 | Children: 5 | Explore Neighborhood | Download JSON

bp(GO:"response to oxidative stress")

In-Edges: 15 | Out-Edges: 12 | Explore Neighborhood | Download JSON

bp(GO:cognition)

In-Edges: 111 | Out-Edges: 35 | Explore Neighborhood | Download JSON

path(MESH:"Alzheimer Disease")

In-Edges: 536 | Out-Edges: 704 | Classes: 5 | Explore Neighborhood | Download JSON

bp(GO:"non-canonical Wnt signaling pathway")

In-Edges: 3 | Out-Edges: 0 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.