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Anti-aggregant tau mutant promotes neurogenesis 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:23:08.033163
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
20
Number Edges
53
Number Components
1
Network Density
0.139473684210526
Average Degree
2.65
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Tau Modifications v1.9.5 35%
Tau in physiology and pathology v1.0.0 30%
Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability v1.0.0 30%
Adenosine A1 receptor antagonist 64627 alleviates axonopathy caused by human Tau ΔK280 v1.0.0 30%
The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0 25%
Caenorhabditis elegans models of tauopathy v1.0.0 25%
mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0 25%
albuquerque2009 v1.0.0 25%
Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0 20%
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro v1.0.0 18%

Sample Edges

p(HBP:"Tau isoform F (441 aa)") hasVariant p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) View Subject | View Object

p(HBP:"Tau isoform F (441 aa)") hasVariant p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

a(CHEBI:doxycycline) decreases p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) View Subject | View Object

However, when the expression of the antiaggregant TauRDΔKPP was switched off by DOX, there was an even more pronounced reduction in Wnt5a level (Fig. 10a, lane 3, bar 3) PubMed:29202785

a(CHEBI:doxycycline) decreases p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) View Subject | View Object

Remarkably, this caused a 40% reduction of the Wnt3 level compared to control slices (Fig. 10b, lane 3, bar 3) PubMed:29202785

a(CHEBI:doxycycline) decreases p(MGI:Wnt5a) View Subject | View Object

However, when the expression of the antiaggregant TauRDΔKPP was switched off by DOX, there was an even more pronounced reduction in Wnt5a level (Fig. 10a, lane 3, bar 3) PubMed:29202785

Sample Nodes

a(MESH:Microglia)

In-Edges: 19 | Out-Edges: 25 | Explore Neighborhood | Download JSON

path(MESH:Inflammation)

In-Edges: 83 | Out-Edges: 41 | Explore Neighborhood | Download JSON

bp(GO:neurogenesis)

In-Edges: 19 | Out-Edges: 4 | Explore Neighborhood | Download JSON

a(MESH:Hippocampus)

In-Edges: 18 | Out-Edges: 14 | Explore Neighborhood | Download JSON

a(MESH:Neurons)

In-Edges: 50 | Out-Edges: 16 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.