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Caenorhabditis elegans models of tauopathy 1.0.0

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Provenance

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charles.hoyt@scai.fraunhofer.de at 2019-03-15 15:44:11.914279
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
113
Number Edges
191
Number Components
1
Network Density
0.0150916561314791
Average Degree
1.69026548672566
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Alzheimer's disease pathological lesions activate the spleen tyrosine kinase. v1.0.0 41%
Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0 38%
Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation v1.0.0 36%
Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease v1.0.0 33%
Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. v1.0.0 33%
Tau Modifications v1.9.5 32%
The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice v1.0.0 31%
Identification of the Tau phosphorylation pattern that drives its aggregation v1.0.0 31%
Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5 v1.0.0 30%
Tau oligomers and tau toxicity in neurodegenerative disease v1.0.0 30%

Sample Edges

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(Ph, Tyr)) View Subject | View Object

p(MESH:Proteins) hasVariant p(MESH:Proteins, pmod(HBP:misfolding)) View Subject | View Object

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(Ph, Ser, 202)) View Subject | View Object

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, var("p.Ala152Thr")) View Subject | View Object

Sample Nodes

a(CHEBI:"amyloid-beta")

In-Edges: 423 | Out-Edges: 245 | Children: 5 | Explore Neighborhood | Download JSON

bp(GO:aging)

In-Edges: 27 | Out-Edges: 61 | Explore Neighborhood | Download JSON

path(MESH:"Alzheimer Disease")

In-Edges: 536 | Out-Edges: 704 | Classes: 5 | Explore Neighborhood | Download JSON

p(HGNC:MAPT)

In-Edges: 477 | Out-Edges: 480 | Classes: 11 | Children: 27 | Explore Neighborhood | Download JSON

p(HGNC:MAPT, pmod(Ph))

In-Edges: 201 | Out-Edges: 71 | Classes: 1 | Children: 4 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.