Upload at 2019-02-27 16:23:06.243256
Kristian Kolpeja
CC BY 4.0
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Tau Modifications v1.9.5 100%
Tau oligomers and tau toxicity in neurodegenerative disease v1.0.0 31%
Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability v1.0.0 31%
Caenorhabditis elegans models of tauopathy v1.0.0 31%
Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0 25%
Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems v1.0.1 23%
Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies v1.0.0 23%
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies v1.0.0 23%
TAU and Interaction Partners v1.2.5 23%
PP2A and Alzheimer Disease v1.0.0 23%

Sample Edges

a(HBP:"Tau Protein Secondary Structure, Turn") decreases a(HBP:"Tau aggregates") View Subject | View Object

Our finding that the resulting Tau species with phosphorylation at Ser202/Th205, but with a disrupted turn-like structure, forms abundant fibers detectable by thioflavin fluorescence or electron microscopy (Figs. 2 and 4) suggests the initial turn-like structure induced by the phosphorylation of only Ser202 and Thr205 is protective against aggregation. PubMed:28784767

a(HBP:"Tau Protein Secondary Structure, Turn") decreases a(HBP:"Tau aggregates") View Subject | View Object

Indeed, Tau phosphorylation at the three positions, Ser202/Thr205/Ser208, while not at Ser262, is sufficient to induce aggregation without the addition of any exogenous aggregation inducer. PubMed:28784767

act(p(FPLX:CSNK1), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 208)) View Subject | View Object

Phosphorylation at Ser208 might be catalyzed by Casein kinase 1 (44), and its identification as a potential site for O-GlcNacylation (45) points to the important role of this residue. PubMed:28784767

Sample Nodes


In-Edges: 477 | Out-Edges: 480 | Classes: 11 | Children: 27 | Explore Neighborhood | Download JSON


In-Edges: 9 | Out-Edges: 9 | Explore Neighborhood | Download JSON

a(HBP:"Tau aggregates")

In-Edges: 224 | Out-Edges: 71 | Children: 3 | Explore Neighborhood | Download JSON

p(HGNC:MAPT, pmod(Ph, Ser, 202))

In-Edges: 45 | Out-Edges: 26 | Equivalencies: 2 | Classes: 2 | Explore Neighborhood | Download JSON


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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.