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p(HGNC:MAPT, pmod(Ph, Ser, 208))

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Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 3

Identification of the Tau phosphorylation pattern that drives its aggregation v1.0.0

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 4

act(p(FPLX:CSNK1), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 208)) View Subject | View Object

Phosphorylation at Ser208 might be catalyzed by Casein kinase 1 (44), and its identification as a potential site for O-GlcNacylation (45) points to the important role of this residue. PubMed:28784767

Appears in Networks:

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(Ph, Ser, 208)) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 208)) View Subject | View Object

3. Putative phosphorylation sites on tau protein and epitopes specific for major tau antibodies. Red color denotes amino acids phosphorylation in AD brain. PubMed:26751493

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 208)) View Subject | View Object

Tau-tubulin kinase 2 (TTBK2) is a Ser/Thr kinase that putatively phosphorylates residues Ser208 and Ser210 (numbered according to a 441-residue human tau isoform) in tau protein. PubMed:17620722

Appears in Networks:

Out-Edges 3

p(HGNC:MAPT, pmod(Ph, Ser, 208)) partOf p(HBP:"Tau epitope, AT8") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph, Ser, 208)) decreases a(HBP:"Tau Protein Secondary Structure, Turn") View Subject | View Object

Indeed, Tau phosphorylation at the three positions, Ser202/Thr205/Ser208, while not at Ser262, is sufficient to induce aggregation without the addition of any exogenous aggregation inducer. PubMed:28784767

Appears in Networks:

p(HGNC:MAPT, pmod(Ph, Ser, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

3. Putative phosphorylation sites on tau protein and epitopes specific for major tau antibodies. Red color denotes amino acids phosphorylation in AD brain. PubMed:26751493

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.