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p(FPLX:CSNK1)

Equivalencies: 0 | Classes: 1 | Children: 7 | Explore

Entity

Name
CSNK1
Namespace
FPLX
Namespace Version
20180917
Namespace URL
https://raw.githubusercontent.com/sorgerlab/famplex/e8ae9926ff95266032cb74f77973c84939bffbeb/export/famplex.belns

Appears in Networks 2

Identification of the Tau phosphorylation pattern that drives its aggregation v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 7

p(HGNC:CSNK1A1) isA p(FPLX:CSNK1) View Subject | View Object

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p(HGNC:CSNK1A1L) isA p(FPLX:CSNK1) View Subject | View Object

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p(HGNC:CSNK1D) isA p(FPLX:CSNK1) View Subject | View Object

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p(HGNC:CSNK1E) isA p(FPLX:CSNK1) View Subject | View Object

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p(HGNC:CSNK1G1) isA p(FPLX:CSNK1) View Subject | View Object

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p(HGNC:CSNK1G2) isA p(FPLX:CSNK1) View Subject | View Object

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p(HGNC:CSNK1G3) isA p(FPLX:CSNK1) View Subject | View Object

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Out-Edges 8

act(p(FPLX:CSNK1), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 208)) View Subject | View Object

Phosphorylation at Ser208 might be catalyzed by Casein kinase 1 (44), and its identification as a potential site for O-GlcNacylation (45) points to the important role of this residue. PubMed:28784767

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p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) View Subject | View Object

We demonstrate that Casein kinase 1 family members, including isoforms of Tau-tubulin protein kinases (TTBK1 and TTBK2), phosphorylate human SV2A at two constellations of residues, namely Cluster-1 (Ser42, Ser45, and Ser47) and Cluster-2 (Ser80, Ser81, and Thr84). These residues are also phosphorylated in vivo, and the phosphorylation of Thr84 within Cluster-2 is essential for triggering binding to the C2B domain of human synaptotagmin-1 PubMed:25673844

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p(FPLX:CSNK1) isA p(HBP:"CK1 superfamily") View Subject | View Object

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p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) View Subject | View Object

We demonstrate that Casein kinase 1 family members, including isoforms of Tau-tubulin protein kinases (TTBK1 and TTBK2), phosphorylate human SV2A at two constellations of residues, namely Cluster-1 (Ser42, Ser45, and Ser47) and Cluster-2 (Ser80, Ser81, and Thr84). These residues are also phosphorylated in vivo, and the phosphorylation of Thr84 within Cluster-2 is essential for triggering binding to the C2B domain of human synaptotagmin-1 PubMed:25673844

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p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) View Subject | View Object

We demonstrate that Casein kinase 1 family members, including isoforms of Tau-tubulin protein kinases (TTBK1 and TTBK2), phosphorylate human SV2A at two constellations of residues, namely Cluster-1 (Ser42, Ser45, and Ser47) and Cluster-2 (Ser80, Ser81, and Thr84). These residues are also phosphorylated in vivo, and the phosphorylation of Thr84 within Cluster-2 is essential for triggering binding to the C2B domain of human synaptotagmin-1 PubMed:25673844

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p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) View Subject | View Object

We demonstrate that Casein kinase 1 family members, including isoforms of Tau-tubulin protein kinases (TTBK1 and TTBK2), phosphorylate human SV2A at two constellations of residues, namely Cluster-1 (Ser42, Ser45, and Ser47) and Cluster-2 (Ser80, Ser81, and Thr84). These residues are also phosphorylated in vivo, and the phosphorylation of Thr84 within Cluster-2 is essential for triggering binding to the C2B domain of human synaptotagmin-1 PubMed:25673844

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p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) View Subject | View Object

We demonstrate that Casein kinase 1 family members, including isoforms of Tau-tubulin protein kinases (TTBK1 and TTBK2), phosphorylate human SV2A at two constellations of residues, namely Cluster-1 (Ser42, Ser45, and Ser47) and Cluster-2 (Ser80, Ser81, and Thr84). These residues are also phosphorylated in vivo, and the phosphorylation of Thr84 within Cluster-2 is essential for triggering binding to the C2B domain of human synaptotagmin-1 PubMed:25673844

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p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) View Subject | View Object

We demonstrate that Casein kinase 1 family members, including isoforms of Tau-tubulin protein kinases (TTBK1 and TTBK2), phosphorylate human SV2A at two constellations of residues, namely Cluster-1 (Ser42, Ser45, and Ser47) and Cluster-2 (Ser80, Ser81, and Thr84). These residues are also phosphorylated in vivo, and the phosphorylation of Thr84 within Cluster-2 is essential for triggering binding to the C2B domain of human synaptotagmin-1 PubMed:25673844

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.