1. Catalog
  2. Networks
  3. The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice v1.0.0

The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice 1.0.0

Compilation Biogrammar
Explore Query

Provenance

Upload
charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:20:50.958560
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
13
Number Edges
13
Number Components
1
Network Density
0.0833333333333333
Average Degree
1.0
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Caenorhabditis elegans models of tauopathy v1.0.0 31%
Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia. v1.0.0 31%
Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1 31%
Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0 23%
Alzheimer's Disease: Targeting the Cholinergic System v1.0.0 23%
A role for b2* nicotinic receptors in a model of local amyloid pathology induced in dentate gyrus v1.0.0 23%
Selective activation of α7 nicotinic acetylcholine receptor by PHA-543613 improves Aβ25-35-mediated cognitive deficits in mice v1.0.0 18%
The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0 15%
Tau in physiology and pathology v1.0.0 15%
Tau Modifications v1.9.5 15%

Sample Edges

a(HBP:"4-OH-GTS-21") increases path(MESH:"Avoidance Learning") View Subject | View Object

Treatment with 4OH-GTS-21 improved performance in both of these paradigms, with drug-induced improvements seen at a lower dose (0.3 mg/kg) in avoidance behavior than in the spatial memory–related task PubMed:17640819

a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory") View Subject | View Object

Improved performance was seen each day in the Morris water task at the 2 mg/kg drug dose compared with saline-injected, lesioned animals PubMed:17640819

a(HBP:"4-OH-GTS-21") causesNoChange bp(GO:locomotion) View Subject | View Object

4OH-GTS-21 had no effect on the latency to enter the dark chamber during avoidance training (Fig. 1 ) or on swim speed in the Morris water task (data not shown), indicating that it had no discernible effect on locomotor function PubMed:17640819

a(HBP:"4-OH-GTS-21") increases a(GO:perikaryon) View Subject | View Object

FFX lesions also reduced the size of the septal cholinergic perikarya in saline-injected wild type mice in a manner that was largely prevented by treatment with 4OH-GTS-21 (Fig. 5) PubMed:17640819

a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"Cholinergic Neurons") View Subject | View Object

4OH-GTS-21 had no effect on cholinergic cell size in the unlesioned sides of the septa of the wild type or PS1 mice, but did cause atrophy of these neurons in the APP/PS1 mice PubMed:17640819

Sample Nodes

a(CHEBI:"amyloid-beta")

In-Edges: 423 | Out-Edges: 245 | Children: 5 | Explore Neighborhood | Download JSON

p(MGI:App)

In-Edges: 2 | Out-Edges: 7 | Explore Neighborhood | Download JSON

a(MESH:"GABAergic Neurons")

In-Edges: 5 | Out-Edges: 1 | Explore Neighborhood | Download JSON

a(MESH:"Cholinergic Neurons")

In-Edges: 20 | Out-Edges: 20 | Explore Neighborhood | Download JSON

bp(GO:locomotion)

In-Edges: 27 | Out-Edges: 3 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.