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composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)))

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Components

Appears in Networks 3

Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome v1.0.0

The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse v1.0.0

Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice v1.0.0

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Out-Edges 6

composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) hasComponent a(PUBCHEM:9832404) View Subject | View Object

Appears in Networks:

composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) hasComponent p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) View Subject | View Object

Appears in Networks:

composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases a(GO:"dendritic spine") View Subject | View Object

Specifically, in Adnp+/+ male mice, we found that NAP treatment reduced hippocampal stubby, thin, and total spine densities (Supplemental Figure 3, P < 0.05) as well as cortical mushroom, stubby, and total densities (Supplemental Figure 4, P < 0.05). PubMed:30106381

Appears in Networks:
Annotations
MeSH
Hippocampus
Gender
Male

composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases path(MESH:Smell) View Subject | View Object

Interestingly, in CB-treated males, Adnp haploinsufficiency showed a reduction in the total time spent with the different odors, which was significantly increased upon NAP treatment (Fig. 2e, inset). PubMed:30664622

Appears in Networks:
Annotations
Gender
Male

composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:Smell) View Subject | View Object

As opposed to this, in females, CB-treated Adnp haploinsufficient mice showed significant increased total odor sniffing time, which was significantly reduced by NAP treatment (Supplemental Fig. S2E, inset). PubMed:30664622

Appears in Networks:
Annotations
Gender
Female

composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:"Alcohol Drinking") View Subject | View Object

Strikingly, NAP treatment reduced alcohol consumption in Adnp+/− mice, which did not differ from Adnp+/+ controls. PubMed:30008470

Appears in Networks:
Annotations
Gender
Female

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.