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Male

Name
Male
Namespace Keyword
Gender
Namespace
Gender
Namespace Version
20170430
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/gender/gender-1.0.0.belanno

Sample Annotated Edges 5

a(PUBCHEM:9832404) increases a(GO:"dendritic spine") View Subject | View Object

The measurements showed similar patterns in both tested brain areas, with Adnp deficiency resulting in substantial decreases in spine density (male and female mice) and increases in PSD95-asymmetric shaft synapses (males only, as indicated by increased localization of PSD95 in dendritic shafts rather than spines), which were all rescued by NAP treatment. PubMed:30106381

Appears in Networks:
Annotations
MeSH
CA1 Region, Hippocampal
MeSH
Cerebral Cortex
MeSH
Pyramidal Cells
Gender
Male
Gender
Female

a(PUBCHEM:9832404) increases a(GO:"dendritic spine") View Subject | View Object

In hippocampal CA1 pyramidal cells, all dendritic spine subtypes were reduced in the Adnp+/– mice, except for the thin spines observed in males. The spine loss was rescued by NAP treatment, except for the stubby spines seen in males (Supplemental Figure 1). PubMed:30106381

Appears in Networks:
Annotations
MeSH
CA1 Region, Hippocampal
MeSH
Pyramidal Cells
Gender
Male
Gender
Female

a(PUBCHEM:9832404) increases a(GO:"dendritic spine") View Subject | View Object

Supplemental Figure 2 shows the cortical spine data indicating a significant genotype effect (P < 0.01) and NAP rescue for all subtypes in males (P < 0.05). PubMed:30106381

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
Gender
Male

a(PUBCHEM:9832404) decreases p(HGNC:DLG4) View Subject | View Object

The measurements showed similar patterns in both tested brain areas, with Adnp deficiency resulting in substantial decreases in spine density (male and female mice) and increases in PSD95-asymmetric shaft synapses (males only, as indicated by increased localization of PSD95 in dendritic shafts rather than spines), which were all rescued by NAP treatment. PubMed:30106381

Appears in Networks:
Annotations
MeSH
CA1 Region, Hippocampal
MeSH
Cerebral Cortex
MeSH
Pyramidal Cells
Gender
Male

a(PUBCHEM:9832404) decreases p(HGNC:DLG4) View Subject | View Object

This genotype- and sex-dependent pathology also extended to the cortex, with increased PSD95 shaft synapse density in Adnp+/– males compared with Adnp+/– females (P < 0.01), and was rescued by NAP treatment. PubMed:30106381

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
Gender
Male

Showing 5 of 77 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.