1. Catalog
  2. Nodes
  3. path(MESH:Smell)

path(MESH:Smell)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Smell
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/mesh-names.belns

Appears in Networks 2

Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome v1.0.0

The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse v1.0.0

In-Edges 9

a(PUBCHEM:9832404) increases path(MESH:Smell) View Subject | View Object

This was coupled with deficits in olfactory function in the Adnp+/– females, but not males, with the female mice exhibiting impaired odor discrimination that was also restored by NAP treatment (Figure 7E; for more detail, see Supplemental Figure 14). PubMed:30106381

Appears in Networks:
Annotations
Gender
Female

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:Smell) View Subject | View Object

This was coupled with deficits in olfactory function in the Adnp+/– females, but not males, with the female mice exhibiting impaired odor discrimination that was also restored by NAP treatment (Figure 7E; for more detail, see Supplemental Figure 14). PubMed:30106381

Appears in Networks:
Annotations
Gender
Female

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:Smell) View Subject | View Object

This was coupled with deficits in olfactory function in the Adnp+/– females, but not males, with the female mice exhibiting impaired odor discrimination that was also restored by NAP treatment (Figure 7E; for more detail, see Supplemental Figure 14). PubMed:30106381

Appears in Networks:
Annotations
Gender
Male

a(CHEBI:chlorobutanol) causesNoChange path(MESH:Smell) View Subject | View Object

As social behavior depends on olfaction, this was also measured showing intact odor discrimination ability in CB-treated males (Fig. 2e) and a sex difference, with no preference for a specific olfactory cue in CB-treated females (Supplemental Fig. S2E), thus corroborating previous findings observed for DD-treated mice PubMed:30664622

Appears in Networks:
Annotations
Gender
Male

a(CHEBI:chlorobutanol) decreases path(MESH:Smell) View Subject | View Object

As social behavior depends on olfaction, this was also measured showing intact odor discrimination ability in CB-treated males (Fig. 2e) and a sex difference, with no preference for a specific olfactory cue in CB-treated females (Supplemental Fig. S2E), thus corroborating previous findings observed for DD-treated mice PubMed:30664622

Appears in Networks:
Annotations
Gender
Female

composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:Smell) View Subject | View Object

Interestingly, in CB-treated males, Adnp haploinsufficiency showed a reduction in the total time spent with the different odors, which was significantly increased upon NAP treatment (Fig. 2e, inset). PubMed:30664622

Appears in Networks:
Annotations
Gender
Male

composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases path(MESH:Smell) View Subject | View Object

As opposed to this, in females, CB-treated Adnp haploinsufficient mice showed significant increased total odor sniffing time, which was significantly reduced by NAP treatment (Supplemental Fig. S2E, inset). PubMed:30664622

Appears in Networks:
Annotations
Gender
Female

composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases path(MESH:Smell) View Subject | View Object

Interestingly, in CB-treated males, Adnp haploinsufficiency showed a reduction in the total time spent with the different odors, which was significantly increased upon NAP treatment (Fig. 2e, inset). PubMed:30664622

Appears in Networks:
Annotations
Gender
Male

composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:Smell) View Subject | View Object

As opposed to this, in females, CB-treated Adnp haploinsufficient mice showed significant increased total odor sniffing time, which was significantly reduced by NAP treatment (Supplemental Fig. S2E, inset). PubMed:30664622

Appears in Networks:
Annotations
Gender
Female

Out-Edges 1

path(MESH:Smell) regulates bp(GO:"social behavior") View Subject | View Object

As social behavior depends on olfaction, this was also measured showing intact odor discrimination ability in CB-treated males (Fig. 2e) and a sex difference, with no preference for a specific olfactory cue in CB-treated females (Supplemental Fig. S2E), thus corroborating previous findings observed for DD-treated mice PubMed:30664622

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.