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Biogrammar Summary of Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease 1.0.0

Table of Contents

  1. Contradictory Pairs
  2. Unstable Pairs
  3. Contradictory Triplets

Contradictory Statements 2

These pairs of nodes have a contradiction in their causal relationships, meaning they have more than one of INCREASES, DECREASES, or CAUSES NO CHANGE. This may be due to different experimental conditions, so these statements need to be carefully considered in analyses.

Source Relations Target
p(MGI:Vegfc) causesNoChange, increases a(CHEBI:macromolecule)
p(MGI:Vegfc) causesNoChange, increases a(MESH:"Lymphatic Vessels")

Unstable Pairs 2

Chaotic Pairs
Nodes that mutually increase each other, such as when both A increases B and B increases A.
Dampened Pairs
Nodes that mutually decrease each other, such as when both A decreases B and B decreases A.

While neither chaotic nor dampened pairs are biologically invalid, they require additional context to understand their regulation.

Type Node A Node B
Chaotic a(MESH:"Lymphatic Vessels") bp(MESH:"Cerebrovascular Circulation")
Chaotic a(MESH:"Lymphatic Vessels") p(MGI:Vegfc)

Contradictory Triplets 3

Analysis of triple stability comes from a deep graph theoretic background. It identifies triangles within the graph that have logically inconsistent relations.

Separately Unstable Triplet
When both A positiveCorrelation B, B negativeCorrelation C, but C positiveCorrelation A.
Mutually Unstable Triplets
When both A negativeCorrelation B, B negativeCorrelation C, and C negativeCorrelation A.
Jens Contradictory Triplet
When A increases B, A decreases C, and C positiveCorrelation A.
Increase Mismatch Triplet
When A increases B, A increases C, and C negativeCorrelation A.
Decrease Mismatch Triplet
When A decreases B, A decreases C, and C negativeCorrelation A.
Type Node A Node B Node C
Jens a(CHEBI:"amyloid-beta") bp(GO:"cerebrospinal fluid circulation") bp(GO:aging)
Jens a(CHEBI:"amyloid-beta") a(HP:"interstitial fluid") bp(GO:aging)
Jens a(CHEBI:"amyloid-beta") a(MESH:"Lymphatic Vessels") bp(GO:aging)

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.