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Silencing of PMT expression caused a surge of anatabine accumulation in tobacco 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-03-15 15:43:44.084453
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
13
Number Edges
21
Number Components
1
Network Density
0.134615384615385
Average Degree
1.61538461538462
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Heme Curation v0.0.1-dev 15%
albuquerque2009 v1.0.0 15%
Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation v1.0.0 15%
Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0 15%
Discriminative Stimulus Properties of S(−)-Nicotine: “A Drug for All Seasons v1.0.0 15%
Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype v1.0.0 12%
Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease v1.0.0 8%
Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0 8%
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System v1.0.0 8%
Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine v1.0.1 8%

Sample Edges

a(CHEBI:"quinolinic acid") increases a(CHEBI:"nicotinic acid") View Subject | View Object

Nicotinic acid is synthesized from quinolinic acid through pyridine nucleotide cycle, and is controlled by quinolinate phosphoribosyltransferase (QPRT) PubMed:19165623

a(CHEBI:arginine) increases a(CHEBI:"1-methylpyrrolinium") View Subject | View Object

N-methyl-Δ1-pyrrolinium is synthesized from arginine and/ or ornithine, and is controlled by putrescine N-methyl transferase (PMT), which is the key enzyme in diverting metabolism towards the biosynthesis of nicotine and others alkaloids [12, 13]. PubMed:19165623

a(CHEBI:ornithine) increases a(CHEBI:"1-methylpyrrolinium") View Subject | View Object

N-methyl-Δ1-pyrrolinium is synthesized from arginine and/ or ornithine, and is controlled by putrescine N-methyl transferase (PMT), which is the key enzyme in diverting metabolism towards the biosynthesis of nicotine and others alkaloids [12, 13]. PubMed:19165623

a(UNIPROT:Q9SEH4) increases a(CHEBI:nicotine) View Subject | View Object

N-methyl-Δ1-pyrrolinium is synthesized from arginine and/ or ornithine, and is controlled by putrescine N-methyl transferase (PMT), which is the key enzyme in diverting metabolism towards the biosynthesis of nicotine and others alkaloids [12, 13]. PubMed:19165623

a(UNIPROT:Q9SEH4) increases a(CHEBI:nicotine) View Subject | View Object

Experiments involving RNA-mediated gene silencing with transgenic Nicotiana plants have shown that a decrease in PMT expression levels can lead to low nicotine content PubMed:19165623

Sample Nodes

a(CHEBI:"quinolinic acid")

In-Edges: 2 | Out-Edges: 14 | Explore Neighborhood | Download JSON

a(CHEBI:nicotine)

In-Edges: 70 | Out-Edges: 181 | Explore Neighborhood | Download JSON

a(CHEBI:Anatabine)

In-Edges: 9 | Out-Edges: 120 | Explore Neighborhood | Download JSON

a(CHEBI:"1-methylpyrrolinium")

In-Edges: 4 | Out-Edges: 0 | Explore Neighborhood | Download JSON

a(CHEBI:"nicotinic acid")

In-Edges: 4 | Out-Edges: 0 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.